biostudies-literatureUnknown45(1)Bargir UACommon Variable Immunodeficiency (CVID) is a heterogeneous disorder characterized by impaired antibody production and recurrent infections. In this study we investigated the clinical and immunological features of CVID in Indian patients and develops a machine learning model for predicting disease severity. We retrospectively analyzed 150 patients diagnosed with CVID over a decade at a tertiary care center in India. The median age of diagnosis was 18 years, with a male predominance (62%). The majority of patients (66.6%) had a severe phenotype, with recurrent respiratory tract infections being the most common clinical manifestation (84.2%). Gastrointestinal complications were observed in 45% of patients, while autoimmune manifestations were seen in 21%. All patients exhibited hypogammaglobuJournal of clinical immunology127https://www.ebi.ac.uk/biostudies/studies/S-EPMC12380919biostudies-literatureCommon Variable Immunodeficiency Disorder: A Decade of Insights from a Cohort of 150 Patients in India and the Use of Machine Learning Algorithms to Predict Severity.PMC12380919Mangalani MShah NGangadharan HChaudhary HKumar PHule GJijina FSetia PGowri VSoneja MGupta MJain PSharma SSharma RNarula GBargir UAZanwar AS CMadkaikar MPai VShinde SKhurana UJose AGanapule AShabrish SDesai MTemkar LBavdekar AVedpathak DBhatia SBhattad STalukdar ISubramaniam GDalvi AAthavale ABalaji SRaj RKini PUpase DJodhawat NSivasankaran MShukla ASengupta AChaudhary NKKalra MGoriwale MYadav RMSaniyal STaur PPetiwala TfalseCommon Variable Immunodeficiency Disorder: A Decade of Insights from a Cohort of 150 Patients in India and the Use of Machine Learning Algorithms to Predict Severity.Common Variable Immunodeficiency (CVID) is a heterogeneous disorder characterized by impaired antibody production and recurrent infections. In this study we investigated the clinical and immunological features of CVID in Indian patients and develops a machine learning model for predicting disease severity. We retrospectively analyzed 150 patients diagnosed with CVID over a decade at a tertiary care center in India. The median age of diagnosis was 18 years, with a male predominance (62%). The majority of patients (66.6%) had a severe phenotype, with recurrent respiratory tract infections being the most common clinical manifestation (84.2%). Gastrointestinal complications were observed in 45% of patients, while autoimmune manifestations were seen in 21%. All patients exhibited hypogammaglobu2025-01-01T00:00:00Z2025 Aug2026-05-10T04:29:29.394Z2026-04-08T01:29:33.694ZS-EPMC123809194085687310.1007/s10875-025-01897-9