{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Demontrond F"],"funding":["Agence Nationale de la Recherche"],"pagination":["e02161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12381689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(48)"],"pubmed_abstract":["Carbohydrate-protein interactions are important in cell-cell communication, signal transduction, cancer, or infection. Chemists have designed glycosylated multivalent systems to mimic these recognition phenomena and produce potent ligands of lectins with therapeutic applications. Dynamic combinatorial chemistry (DCC) provides access to libraries of glycosylated macrocycles equilibrating through reversible covalent bonds. This strategy can be applied to the rapid and efficient identification of multivalent glycoclusters by introducing a protein into the equilibrating library. This strategy allowed the identification of the best ligands for more than one lectin in a single experimental set up by using two simple 1,4-dithiophenol building blocks. Selection of the best binder by each lectin (C"],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Dynamic Combinatorial Chemistry Generates Adaptative Libraries of Glyco-Dyn[n]Arenes That can Be Templated to Produce Anti-Adhesive Glycoconjugates Targeting Pseudomonas aeruginosa."],"pmcid":["PMC12381689"],"funding_grant_id":["ANR‐17‐CE07‐0054","ANR-17-CE07-0054"],"pubmed_authors":["Raillon C","Galia W","Leclaire J","Gueyrard D","Demontrond F","Donnier-Marechal M","Berger E","Cournoyer B","Geloen A","Tramblais C","Luton B","Vial L","Vidal S","Pascal Y"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic Combinatorial Chemistry Generates Adaptative Libraries of Glyco-Dyn[n]Arenes That can Be Templated to Produce Anti-Adhesive Glycoconjugates Targeting Pseudomonas aeruginosa.","description":"Carbohydrate-protein interactions are important in cell-cell communication, signal transduction, cancer, or infection. Chemists have designed glycosylated multivalent systems to mimic these recognition phenomena and produce potent ligands of lectins with therapeutic applications. Dynamic combinatorial chemistry (DCC) provides access to libraries of glycosylated macrocycles equilibrating through reversible covalent bonds. This strategy can be applied to the rapid and efficient identification of multivalent glycoclusters by introducing a protein into the equilibrating library. This strategy allowed the identification of the best ligands for more than one lectin in a single experimental set up by using two simple 1,4-dithiophenol building blocks. Selection of the best binder by each lectin (C","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-10T04:37:27.679Z","creation":"2026-04-08T01:30:08.272Z"},"accession":"S-EPMC12381689","cross_references":{"pubmed":["40772720"],"doi":["10.1002/chem.202502161"]}}