{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(8)"],"submitter":["Nunes GAMA"],"pubmed_abstract":["Organ-on-a-chip (OoC) devices simulate human organs within a microenvironment, potentially surpassing traditional preclinical methods and paving the way for innovative treatments. A thorough understanding of the current state of OoC design enables the development of more precise and relevant models that replicate not only the structure of organs but also their intricate cellular interactions and responses to external stimuli. This knowledge facilitates the optimization of biomimetic materials and allows for the real-time simulation of physiological microenvironments. By keeping abreast of new microfabrication techniques, we can explore opportunities to create customized and highly functional OoCs. To provide a comprehensive overview of microphysiological platform designs. This systematic r"],"journal":["Biomimetics (Basel, Switzerland)"],"pagination":["524"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12383757"],"repository":["biostudies-literature"],"pubmed_title":["State-of-the-Art Organ-on-Chip Models and Designs for Medical Applications: A Systematic Review."],"pmcid":["PMC12383757"],"pubmed_authors":["Santos KS","Carneiro MLB","Nunes GAMA","Fleury Rosa SSR","Faria RM","da Rocha AF","Aguiar ADC","Luz GVDS","Gomes AKGB","Barreto Mota da Costa L","Rosa MFF","da Silva AKA","Ibiapina KM","Joanitti GA"],"additional_accession":[]},"is_claimable":false,"name":"State-of-the-Art Organ-on-Chip Models and Designs for Medical Applications: A Systematic Review.","description":"Organ-on-a-chip (OoC) devices simulate human organs within a microenvironment, potentially surpassing traditional preclinical methods and paving the way for innovative treatments. A thorough understanding of the current state of OoC design enables the development of more precise and relevant models that replicate not only the structure of organs but also their intricate cellular interactions and responses to external stimuli. This knowledge facilitates the optimization of biomimetic materials and allows for the real-time simulation of physiological microenvironments. By keeping abreast of new microfabrication techniques, we can explore opportunities to create customized and highly functional OoCs. To provide a comprehensive overview of microphysiological platform designs. This systematic r","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T10:42:42.433Z","creation":"2026-04-08T01:32:26.841Z"},"accession":"S-EPMC12383757","cross_references":{"pubmed":["40862897"],"doi":["10.3390/biomimetics10080524"]}}