{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Azmoun S"],"funding":["NIEHS NIH HHS","NINDS NIH HHS","National Institutes of Health (NIH), University of Georgia Diane Isakson Distinguished Professorship, the European Union through its Sixth Framework Programme"],"pagination":["829"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12384076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(8)"],"pubmed_abstract":["<h4>Background</h4>There is growing interest in the potential role of manganese (Mn) in the development of Alzheimer's Disease and related dementias (ADRD).<h4>Methods</h4>In this nested pilot study of a ferroalloy worker cohort, we investigated the impact of chronic occupational Mn exposure on cognitive function through β-amyloid (Aβ) deposition and multi-omics profiling. We evaluated six male Mn-exposed workers (median age 63, exposure duration 31 years) and five historical controls (median age: 60 years), all of whom had undergone brain PET scans. Exposed individuals showed significantly higher Aβ deposition in exposed individuals (<i>p</i> < 0.05). The average annual cumulative respirable Mn was 329.23 ± 516.39 µg/m<sup>3</sup> (geometric mean 118.59), and plasma Mn levels were signifi"],"journal":["Brain sciences"],"pubmed_title":["Impact of Manganese on Neuronal Function: An Exploratory Multi-Omics Study on Ferroalloy Workers in Brescia, Italy."],"pmcid":["PMC12384076"],"funding_grant_id":["T32 ES033955","National Institutes of Health (NIH) grants numbers R01 ES019222, P30ES023515, RF1NS130713, R01AG085729, the University of Georgia Diane Isakson Distinguished Professorship, the European Union through its Sixth Framework Programme (contract number FOOD-CT-","RF1 NS130713","P30 ES023515","R01 ES019222"],"pubmed_authors":["Azmoun S","Mhatre-Winters I","Placidi D","Gu H","Lucchini RG","Lambertini L","Richardson JR","Colicino E","Shoieb D","Jin Y","Krishnamurthy H","Lewis FC"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Manganese on Neuronal Function: An Exploratory Multi-Omics Study on Ferroalloy Workers in Brescia, Italy.","description":"<h4>Background</h4>There is growing interest in the potential role of manganese (Mn) in the development of Alzheimer's Disease and related dementias (ADRD).<h4>Methods</h4>In this nested pilot study of a ferroalloy worker cohort, we investigated the impact of chronic occupational Mn exposure on cognitive function through β-amyloid (Aβ) deposition and multi-omics profiling. We evaluated six male Mn-exposed workers (median age 63, exposure duration 31 years) and five historical controls (median age: 60 years), all of whom had undergone brain PET scans. Exposed individuals showed significantly higher Aβ deposition in exposed individuals (<i>p</i> < 0.05). The average annual cumulative respirable Mn was 329.23 ± 516.39 µg/m<sup>3</sup> (geometric mean 118.59), and plasma Mn levels were signifi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-04-08T19:31:09.364Z","creation":"2026-04-08T13:43:20.938Z"},"accession":"S-EPMC12384076","cross_references":{"pubmed":["40867161"],"doi":["10.3390/brainsci15080829"]}}