{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu X"],"funding":["Liaoning Province Health and Wellness Appropriate Technology Promotion Project, China"],"pagination":["e43976"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12384908"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["104(34)"],"pubmed_abstract":["Resistance training (RT) is a fundamental sarcopenia treatment, but its efficacy may be enhanced by nutritional strategies. This study investigated whether combining RT with vitamins C and E supplementation yields additive benefits in sarcopenia patients. Sixty older women with sarcopenia (60-75 years) were randomized to an antioxidant supplementation group (AS; 1000 mg/d vitamin C and 335 mg/d vitamin E) or a placebo group (PLA) following the same elastic-band RT program. Muscle mass, muscle strength, physical performance, oxidative stress-related indices (reduced glutathione [GSH] and oxidized glutathione [GSSG], GSH/GSSG ratio, malondialdehyde, and protein carbonyl), and pro-inflammatory factors (interleukin-6 [IL-6] and tumor necrosis factor-alpha) were evaluated at baseline and after "],"journal":["Medicine"],"pubmed_title":["Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial."],"pmcid":["PMC12384908"],"funding_grant_id":["2021180107"],"pubmed_authors":["Liu X","Li Y","Li C","Zhang Y","Zhong F","Wu B","Xu S","Chen X","Jin Y","Chen B","Cui R"],"additional_accession":[]},"is_claimable":false,"name":"Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial.","description":"Resistance training (RT) is a fundamental sarcopenia treatment, but its efficacy may be enhanced by nutritional strategies. This study investigated whether combining RT with vitamins C and E supplementation yields additive benefits in sarcopenia patients. Sixty older women with sarcopenia (60-75 years) were randomized to an antioxidant supplementation group (AS; 1000 mg/d vitamin C and 335 mg/d vitamin E) or a placebo group (PLA) following the same elastic-band RT program. Muscle mass, muscle strength, physical performance, oxidative stress-related indices (reduced glutathione [GSH] and oxidized glutathione [GSSG], GSH/GSSG ratio, malondialdehyde, and protein carbonyl), and pro-inflammatory factors (interleukin-6 [IL-6] and tumor necrosis factor-alpha) were evaluated at baseline and after ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-10T04:55:43.161Z","creation":"2026-04-08T01:32:22.842Z"},"accession":"S-EPMC12384908","cross_references":{"pubmed":["40859523"],"doi":["10.1097/MD.0000000000043976"]}}