biostudies-literatureLiu XLiaoning Province Health and Wellness Appropriate Technology Promotion Project, Chinae43976https://www.ebi.ac.uk/biostudies/studies/S-EPMC12384908biostudies-literatureUnknown104(34)Resistance training (RT) is a fundamental sarcopenia treatment, but its efficacy may be enhanced by nutritional strategies. This study investigated whether combining RT with vitamins C and E supplementation yields additive benefits in sarcopenia patients. Sixty older women with sarcopenia (60-75 years) were randomized to an antioxidant supplementation group (AS; 1000 mg/d vitamin C and 335 mg/d vitamin E) or a placebo group (PLA) following the same elastic-band RT program. Muscle mass, muscle strength, physical performance, oxidative stress-related indices (reduced glutathione [GSH] and oxidized glutathione [GSSG], GSH/GSSG ratio, malondialdehyde, and protein carbonyl), and pro-inflammatory factors (interleukin-6 [IL-6] and tumor necrosis factor-alpha) were evaluated at baseline and after MedicineEffects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial.PMC123849082021180107Liu XLi YLi CZhang YZhong FWu BXu SChen XJin YChen BCui RfalseEffects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial.Resistance training (RT) is a fundamental sarcopenia treatment, but its efficacy may be enhanced by nutritional strategies. This study investigated whether combining RT with vitamins C and E supplementation yields additive benefits in sarcopenia patients. Sixty older women with sarcopenia (60-75 years) were randomized to an antioxidant supplementation group (AS; 1000 mg/d vitamin C and 335 mg/d vitamin E) or a placebo group (PLA) following the same elastic-band RT program. Muscle mass, muscle strength, physical performance, oxidative stress-related indices (reduced glutathione [GSH] and oxidized glutathione [GSSG], GSH/GSSG ratio, malondialdehyde, and protein carbonyl), and pro-inflammatory factors (interleukin-6 [IL-6] and tumor necrosis factor-alpha) were evaluated at baseline and after 2025-01-01T00:00:00Z2025 Aug2026-05-10T04:55:43.161Z2026-04-08T01:32:22.842ZS-EPMC123849084085952310.1097/MD.0000000000043976