{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei Y"],"funding":["Natural Sciences and Engineering Research Council of Canada","NIDA NIH HHS","NIAID NIH HHS","National Institutes of Health"],"pagination":["2878-2898.e11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12385486"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(11)"],"pubmed_abstract":["Tissue-resident memory T cells (Trms) are essential for mucosal immunity. We postulated that their long-lived tissue residency and restricted effector function promoted HIV-1 persistence in the gut. We coupled single-cell DOGMA-seq and TREK-seq to capture chromatin accessibility, transcriptome, surface proteins, T cell receptors (TCRs), HIV-1 DNA, and HIV-1 RNA in gut CD4<sup>+</sup> and CD8<sup>+</sup> T cells from ten aviremic HIV-1<sup>+</sup> individuals and five HIV<sup>-</sup> donors. BACH2, a transcriptional repressor that establishes long-lived memory in T cells, was a key transcription factor that shaped gut Trms into long-lived memory and restrained interferon-driven effector function. BACH2-ablation shifted long-lived central memory T cells to effector memory. HIV-1-infected cel"],"journal":["Immunity"],"pubmed_title":["Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence."],"pmcid":["PMC12385486"],"funding_grant_id":["M-SCORCH U01 DA053628","U01 AI110434","R33 DA047037","R01 AI141009","R01 AI174863","R01 DA051906","R01 AI176601","UM1 AI164570","Y-SCORCH UM1 DA051410","UM1 AI164565","R01 AI183430","P01 AI169768","UM1 DA051410","CHEETAH U54 AI170856","UM1 AI191272","REACH UM1 AI164565","U54 AI170856","U01 DA053628"],"pubmed_authors":["Papasavvas E","Wong ME","Tebas P","Ma HK","Aberra F","Konnikova L","Back H","Morgenstern R","Montaner LJ","Ho YC","Mounzer K","Wei Y"],"additional_accession":[]},"is_claimable":false,"name":"Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence.","description":"Tissue-resident memory T cells (Trms) are essential for mucosal immunity. We postulated that their long-lived tissue residency and restricted effector function promoted HIV-1 persistence in the gut. We coupled single-cell DOGMA-seq and TREK-seq to capture chromatin accessibility, transcriptome, surface proteins, T cell receptors (TCRs), HIV-1 DNA, and HIV-1 RNA in gut CD4<sup>+</sup> and CD8<sup>+</sup> T cells from ten aviremic HIV-1<sup>+</sup> individuals and five HIV<sup>-</sup> donors. BACH2, a transcriptional repressor that establishes long-lived memory in T cells, was a key transcription factor that shaped gut Trms into long-lived memory and restrained interferon-driven effector function. BACH2-ablation shifted long-lived central memory T cells to effector memory. HIV-1-infected cel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-07-16T21:58:35.17Z","creation":"2026-07-11T03:09:01.409Z"},"accession":"S-EPMC12385486","cross_references":{"pubmed":["40845842"],"doi":["10.1016/j.immuni.2025.07.022"]}}