{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Buscemi S"],"funding":["Ministero dell'università e della ricerca"],"pagination":["297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12387130"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(8)"],"pubmed_abstract":["Background: Common bile duct (CBD) treatments are often associated with complications, limiting long-term efficacy. To overcome these issues, polymeric grafts have been suggested as promising alternatives, since they are highly customizable, biocompatible, and may reduce side effects frequency. Methods: A systematic review was conducted, interrogating MEDLINE and Cochrane Library. Next, an in vivo study involved 20 pigs, which underwent a former controlled biliary injury. To repair the defect, a α,β-Poly(N-2-hydroxyethyl)-DL-Aspartamide (PHEA)-Polylactic-acid (PLA)-Polycaprolactone (PCL) scaffold was implanted. The animals were sacrificed at one and three months for gross and histological examinations, to assess tissue integration and healing outcomes. Results: The systematic review highli"],"journal":["Journal of functional biomaterials"],"pubmed_title":["Biliary Injuries Repair Using Copolymeric Scaffold: A Systematic Review and In Vivo Experimental Study."],"pmcid":["PMC12387130"],"funding_grant_id":["Linea di attività: AIM1892002 - 3, CUP B78D18002280006"],"pubmed_authors":["Cicero L","Bonventre G","Gottardo A","Cassata G","Puleio R","Licciardi M","Lo Monte AI","Lo Monte G","Palumbo FS","Buscemi S"],"additional_accession":[]},"is_claimable":false,"name":"Biliary Injuries Repair Using Copolymeric Scaffold: A Systematic Review and In Vivo Experimental Study.","description":"Background: Common bile duct (CBD) treatments are often associated with complications, limiting long-term efficacy. To overcome these issues, polymeric grafts have been suggested as promising alternatives, since they are highly customizable, biocompatible, and may reduce side effects frequency. Methods: A systematic review was conducted, interrogating MEDLINE and Cochrane Library. Next, an in vivo study involved 20 pigs, which underwent a former controlled biliary injury. To repair the defect, a α,β-Poly(N-2-hydroxyethyl)-DL-Aspartamide (PHEA)-Polylactic-acid (PLA)-Polycaprolactone (PCL) scaffold was implanted. The animals were sacrificed at one and three months for gross and histological examinations, to assess tissue integration and healing outcomes. Results: The systematic review highli","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T10:33:15.189Z","creation":"2026-04-08T01:30:03.54Z"},"accession":"S-EPMC12387130","cross_references":{"pubmed":["40863317"],"doi":["10.3390/jfb16080297"]}}