biostudies-literatureBuscemi SMinistero dell'università e della ricerca297https://www.ebi.ac.uk/biostudies/studies/S-EPMC12387130biostudies-literatureUnknown16(8)Background: Common bile duct (CBD) treatments are often associated with complications, limiting long-term efficacy. To overcome these issues, polymeric grafts have been suggested as promising alternatives, since they are highly customizable, biocompatible, and may reduce side effects frequency. Methods: A systematic review was conducted, interrogating MEDLINE and Cochrane Library. Next, an in vivo study involved 20 pigs, which underwent a former controlled biliary injury. To repair the defect, a α,β-Poly(N-2-hydroxyethyl)-DL-Aspartamide (PHEA)-Polylactic-acid (PLA)-Polycaprolactone (PCL) scaffold was implanted. The animals were sacrificed at one and three months for gross and histological examinations, to assess tissue integration and healing outcomes. Results: The systematic review highliJournal of functional biomaterialsBiliary Injuries Repair Using Copolymeric Scaffold: A Systematic Review and In Vivo Experimental Study.PMC12387130Linea di attività: AIM1892002 - 3, CUP B78D18002280006Cicero LBonventre GGottardo ACassata GPuleio RLicciardi MLo Monte AILo Monte GPalumbo FSBuscemi SfalseBiliary Injuries Repair Using Copolymeric Scaffold: A Systematic Review and In Vivo Experimental Study.Background: Common bile duct (CBD) treatments are often associated with complications, limiting long-term efficacy. To overcome these issues, polymeric grafts have been suggested as promising alternatives, since they are highly customizable, biocompatible, and may reduce side effects frequency. Methods: A systematic review was conducted, interrogating MEDLINE and Cochrane Library. Next, an in vivo study involved 20 pigs, which underwent a former controlled biliary injury. To repair the defect, a α,β-Poly(N-2-hydroxyethyl)-DL-Aspartamide (PHEA)-Polylactic-acid (PLA)-Polycaprolactone (PCL) scaffold was implanted. The animals were sacrificed at one and three months for gross and histological examinations, to assess tissue integration and healing outcomes. Results: The systematic review highli2025-01-01T00:00:00Z2025 Aug2026-04-08T10:33:15.189Z2026-04-08T01:30:03.54ZS-EPMC123871304086331710.3390/jfb16080297