{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Karlsberger L"],"funding":["Christian Doppler Research Association","Austrian Research Promotion Agency"],"pagination":["322"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12387151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(8)"],"pubmed_abstract":["Brown algae such as <i>Ascophyllum nodosum</i> (AN) and <i>Fucus vesiculosus</i> (FV) are gaining considerable attention as functional feed additives due to their health-beneficial properties. This study evaluated the antioxidant potential of AN and FV extracts in intestinal epithelial cells and the in vivo model <i>Caenorhabditis elegans</i> (<i>C. elegans</i>). Aqueous AN and FV extracts were characterized for total phenolic content (TPC), antioxidant capacity (TEAC, FRAP), and phlorotannin composition using LC-HRMS/MS. Antioxidant effects were assessed in vitro, measuring AAPH-induced ROS production in Caco-2 and IPEC-J2 cells via H<sub>2</sub>DCF-DA, and in vivo, evaluating the effects of paraquat-induced oxidative stress and AN or FV treatment on worm motility, GST-4::GFP reporter exp"],"journal":["Marine drugs"],"pubmed_title":["Antioxidant Power of Brown Algae: &lt;i&gt;Ascophyllum nodosum&lt;/i&gt; and &lt;i&gt;Fucus vesiculosus&lt;/i&gt; Extracts Mitigate Oxidative Stress In Vitro and In Vivo."],"pmcid":["PMC12387151"],"funding_grant_id":["905123","881882","Josef Ressel Center for Phytogenic Drug Research"],"pubmed_authors":["Weghuber J","Molcanova L","Karlsberger L","Ladirat S","Sandner G","Rypar T"],"additional_accession":[]},"is_claimable":false,"name":"Antioxidant Power of Brown Algae: &lt;i&gt;Ascophyllum nodosum&lt;/i&gt; and &lt;i&gt;Fucus vesiculosus&lt;/i&gt; Extracts Mitigate Oxidative Stress In Vitro and In Vivo.","description":"Brown algae such as <i>Ascophyllum nodosum</i> (AN) and <i>Fucus vesiculosus</i> (FV) are gaining considerable attention as functional feed additives due to their health-beneficial properties. This study evaluated the antioxidant potential of AN and FV extracts in intestinal epithelial cells and the in vivo model <i>Caenorhabditis elegans</i> (<i>C. elegans</i>). Aqueous AN and FV extracts were characterized for total phenolic content (TPC), antioxidant capacity (TEAC, FRAP), and phlorotannin composition using LC-HRMS/MS. Antioxidant effects were assessed in vitro, measuring AAPH-induced ROS production in Caco-2 and IPEC-J2 cells via H<sub>2</sub>DCF-DA, and in vivo, evaluating the effects of paraquat-induced oxidative stress and AN or FV treatment on worm motility, GST-4::GFP reporter exp","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T15:54:04.567Z","creation":"2026-04-08T05:44:33.235Z"},"accession":"S-EPMC12387151","cross_references":{"pubmed":["40863639"],"doi":["10.3390/md23080322"]}}