{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Campodonico E"],"pubmed_abstract":["Hemophagocytic lymphohistiocytosis (HLH) is a hyper-inflammatory syndrome characterized by deficient NK-cell activity, cytokine storm and altered T-cell immunity, potentially sustained by multiple triggers. Recently, a hyperinflammatory condition resembling HLH has emerged as a potential complication of CAR T-cells. HLH represents a diagnostic conundrum due to its rarity, non-specific presentation and lack of validated biomarkers. We investigated a panel of serum cytokines which represent candidate markers to diagnose HLH after CAR-T. We analyzed 2 patients affected by B-cell lymphomas who received anti-CD19 CAR-T and developed HLH defined according to multiple diagnostic criteria. We identified four controls who did not develop HLH: one with CRS without cytopenia, one with cytopenia with "],"journal":["Frontiers in immunology"],"pagination":["1635062"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12390792"],"repository":["biostudies-literature"],"pubmed_title":["Biomarkers for an early diagnosis of immune effector cell associated-hemophagocytic syndrome."],"pmcid":["PMC12390792"],"pubmed_authors":["Lupo Stanghellini MT","Ruggeri A","Angelillo P","Noviello M","Doglio M","Carrabba MG","Bruno A","Pedica F","Bergonzi GM","Peccatori J","Ciceri F","Diral E","Corti C","Ferreri AJM","Bonini C","Greco R","Campodonico E","Lazzari L","Ugolini A","Tassi E","Ponzoni M"],"additional_accession":[]},"is_claimable":false,"name":"Biomarkers for an early diagnosis of immune effector cell associated-hemophagocytic syndrome.","description":"Hemophagocytic lymphohistiocytosis (HLH) is a hyper-inflammatory syndrome characterized by deficient NK-cell activity, cytokine storm and altered T-cell immunity, potentially sustained by multiple triggers. Recently, a hyperinflammatory condition resembling HLH has emerged as a potential complication of CAR T-cells. HLH represents a diagnostic conundrum due to its rarity, non-specific presentation and lack of validated biomarkers. We investigated a panel of serum cytokines which represent candidate markers to diagnose HLH after CAR-T. We analyzed 2 patients affected by B-cell lymphomas who received anti-CD19 CAR-T and developed HLH defined according to multiple diagnostic criteria. We identified four controls who did not develop HLH: one with CRS without cytopenia, one with cytopenia with ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-29T15:15:45.067Z","creation":"2026-04-08T05:12:12.67Z"},"accession":"S-EPMC12390792","cross_references":{"pubmed":["40895549"],"doi":["10.3389/fimmu.2025.1635062"]}}