biostudies-literatureMunroe ESNHLBI NIH HHSNIGMS NIH HHSe2529148https://www.ebi.ac.uk/biostudies/studies/S-EPMC12391982biostudies-literatureUnknown8(8)<h4>Importance</h4>Evidence supporting the safety of infusing vasopressors through peripheral intravenous catheters (peripheral vasopressors) is largely derived from single-center studies, limiting generalizability.<h4>Objective</h4>To evaluate factors associated with vasopressor route selection and assess safety and clinical outcomes of peripheral vasopressor administration in early sepsis resuscitation.<h4>Design, setting, and participants</h4>This prospective cohort study is a secondary analysis of the Crystalloid Liberal vs Early Vasopressors in Sepsis (CLOVERS) trial conducted in 60 US hospitals from March 2018 to February 2022. Patients in CLOVERS who received vasopressors within 24 hours of enrollment and did not have central venous access at enrollment were included. Data were analJAMA network openPeripheral Vasopressor Use in Early Sepsis-Induced Hypotension.PMC12391982R35 GM151147K23 HL177175L30 HL170379Tidswell MWilliams MDouglas IMiru DKass LEThomspon BTPiserchia KSochor MLyle CHall JRPatel BWest MWeinmann GSiegel MChang SYMoskowitz AEppensteiner JHastings AParsons POullette SWang HEPark PKFreemer MKoehler LWallick JBaron RMWeissman AMorris PEBledsoe JZouyed ZJohnson NJHough CLKozikowski LSchooler JSiner JMDouglas ISFletcher DLevy MLavin-Parsons KKarow SCAndreo KLevitt JEAngus DCHendey GWLeither LMNHLBI PETAL NetworkTerry CGundel SFergus MDemissie ENatt BHuang DTPlante AdeBoisblanc BLammi MShapiro NINkemdirim WNewton MLopez BMiller CDonnelly HDugar SHaukoos JPaxton JEnfield KKamel MYoungquist SPeltan IDMeza JTzehaie HArsenault PChiu DCresie AUlysse CKeenawinna LSeghal SParry BAQuackenbush EBFung CMMcGarry STorbati SWaddoups LJMaher PPulido NSchoenfeld DAHudock KMBorg BADean STalmor DO'Mara TWilson JGTurturro MADuven AGalbraith JAlbertson TEHowell MHubel KJimenez JVReimer HFitzgerald LArmbruster BApplegate DGillespie MNFinck LMassaro AFChen PHypes CSteingrub JSKrol OVojnik RMechanic ONelson KSandrock CJones AEStaugaitis ABoyle KFlores LBelsky JBGinde AAAggarwal NGarcia AHaq ECassity EPKeegan SMuzikansky ACasey JDVidales EMehkri OJohnson JAshok KJiang KKatsandres SLagakos AGrady ADickert NAlmarsi EPetersen EMontgomery-Yates AAisiku IPKryscio RJKurt LCo INMcVerry BJChristie JDPage DBWillig MBoujid SCampbell ESScales DFilbin MRGong MNBouffler ATran TXSeethala RRSigel PStoianoff SMorrison LJHibbert KStylianou MOlbrich NBienstock KHou PHindoyan NLim GGentile NTFerrante LEMoss MDuggal AFiles DCLai PHarris ERowland MMock JElie MCSyed APeltan IHayes SAston VSimpson ASeelye SPrescott HCThornton-Thompson SMatthay MBaughman ABanner-Goodspeed VMarliere MHHays MMaclawiw MDiercks DMunroe ESCampbell CMSturgill JPrecopio LNJanz DBrown SMSelf WHMontgomery QNandi UAdeoye OKunz LHughes AAcquah SCarson SSHayden DLNash JBreslin ARomain SOldmixon CDhar SHorton NJRice CBecker TKTerndrup TELematty CPeacock RAshktorab KMason JSousa KRogers AJFuentes MOliva CGibbs KWKiley JHarris DSShaw MTrent SBenitez EQadir NKardos CPuskarich MAMcSparron JIPugh SKirk CHappel KHendrickson AJaton EKapoor RMosier JMCox CTam ARussell DWReineck LADe Souza LAgrawal AGoel NPrekker MEde Wit MJouzestani MKGravitz SMcKeehan JHuang WRaddell THellman MSather JEPearson SJStang JExline MCRice TWRobinson BRReilkoff RAJackman SHiggins CBischof JJHyder EWira CRHanna SDubosh NRichardson LDBrokowski CRamser ELBrower RGHuebinger RCairns CBChenoweth JAWunderink RSherwin RYealy DMGoodwin AJWhitaker SHiller TRingwood NYee KSchermerhorn MEhrman RAydin ABrodie DEnglert JAMathews KHite RDBeutler RMiddleton EAStiell IChen JTNair RHardy EMarchetti NMorse RPaine RZoloth LSLimkakeng ATHarrison KMorin HHyzy RMarshall MO'Mahony SLaRose MRomaine CMohamed AKhan ASmithline HWilburn JLauto PGropper RDeVries PFrey JASandi MCSmith RBrown KRoque JCourtney DMde Souza Licht AfalsePeripheral Vasopressor Use in Early Sepsis-Induced Hypotension.<h4>Importance</h4>Evidence supporting the safety of infusing vasopressors through peripheral intravenous catheters (peripheral vasopressors) is largely derived from single-center studies, limiting generalizability.<h4>Objective</h4>To evaluate factors associated with vasopressor route selection and assess safety and clinical outcomes of peripheral vasopressor administration in early sepsis resuscitation.<h4>Design, setting, and participants</h4>This prospective cohort study is a secondary analysis of the Crystalloid Liberal vs Early Vasopressors in Sepsis (CLOVERS) trial conducted in 60 US hospitals from March 2018 to February 2022. Patients in CLOVERS who received vasopressors within 24 hours of enrollment and did not have central venous access at enrollment were included. Data were anal2025-01-01T00:00:00Z2025 Aug2026-07-15T14:19:04.371Z2026-07-09T10:15:32.379ZS-EPMC123919824086446710.1001/jamanetworkopen.2025.29148