{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Song Y"],"pubmed_abstract":["Altitude adaptation is a complex process involving multiple physiological and biochemical responses to hypoxia and other environmental stresses. In-depth genetic analysis of Tibetan sheep, which exhibit significant adaptations to high-altitude hypoxia, promises to elucidate hypoxia-tolerance mechanisms in plateau animals. Here, we conducted a genome-wide selection scan on three Tibetan sheep populations: low-altitude Tao (TS; 2887 m), medium-altitude Tianjun white (WT; 3331 m), and high-altitude Huoerba (HB; 4614 m). Using the population differentiation index (Fst) and nucleotide diversity (θπ) ratio, we analyzed selection signals associated with hypoxia at high-altitudes. We screened 865, 941, and 876 candidate genes in the TS vs. WT, TS vs. HB, and WT vs. HB group comparisons, respective"],"journal":["Frontiers in veterinary science"],"pagination":["1632017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12392279"],"repository":["biostudies-literature"],"pubmed_title":["Genome-wide selection signal analysis reveals the adaptability of Tibetan sheep to high altitudes."],"pmcid":["PMC12392279"],"pubmed_authors":["Yuan C","Liu J","Lu Z","Wang F","Guo T","Chen B","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide selection signal analysis reveals the adaptability of Tibetan sheep to high altitudes.","description":"Altitude adaptation is a complex process involving multiple physiological and biochemical responses to hypoxia and other environmental stresses. In-depth genetic analysis of Tibetan sheep, which exhibit significant adaptations to high-altitude hypoxia, promises to elucidate hypoxia-tolerance mechanisms in plateau animals. Here, we conducted a genome-wide selection scan on three Tibetan sheep populations: low-altitude Tao (TS; 2887 m), medium-altitude Tianjun white (WT; 3331 m), and high-altitude Huoerba (HB; 4614 m). Using the population differentiation index (Fst) and nucleotide diversity (θπ) ratio, we analyzed selection signals associated with hypoxia at high-altitudes. We screened 865, 941, and 876 candidate genes in the TS vs. WT, TS vs. HB, and WT vs. HB group comparisons, respective","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-29T17:53:17.108Z","creation":"2026-04-08T05:43:10.392Z"},"accession":"S-EPMC12392279","cross_references":{"pubmed":["40895789"],"doi":["10.3389/fvets.2025.1632017"]}}