{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Q"],"funding":["Agricultural Research Project of Zhejiang Provincial (Xingfeng Shao)","National Science Foundation of China (Feng Xu)","State Key Laboratory for the Quality and Safety of Agro-products (Yingying Wei)"],"pagination":["3524-3539"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12392935"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Transcription factors MYC2 and JAMs play a crucial role in regulating disease resistance in model plants. However, their regulatory mechanisms of disease resistance in non-model plants, particularly in postharvest fruits, remain largely unknown. In this study, we observed that PpMYC2 expression was up-regulated in peach fruit following infection by Monilinia fructicola, while the expressions of PpJAM2/3 were down-regulated. Furthermore, we found that PpMYC2 positively regulated the resistance against M. fructicola, whereas PpJAM2/3 negatively regulated it. Through a combined DNA affinity purification and RNA sequencing analysis for PpMYC2, we identified lignin synthesis genes (PpPAL1, PpC4H, Pp4CL1, PpCSE and PpCCoAOMT1) as candidate target genes. Subsequent assays, including dual-lucifera"],"journal":["Plant biotechnology journal"],"pubmed_title":["PpMYC2 and PpJAM2/3 antagonistically regulate lignin synthesis to cope with the disease in peach fruit."],"pmcid":["PMC12392935"],"funding_grant_id":["2024SNJF025","U23A20264","2021DG700024-KF202423"],"pubmed_authors":["Shao X","Chen J","Li Q","Chen Y","Jiang S","Xu F","Wei Y","Ye J"],"additional_accession":[]},"is_claimable":false,"name":"PpMYC2 and PpJAM2/3 antagonistically regulate lignin synthesis to cope with the disease in peach fruit.","description":"Transcription factors MYC2 and JAMs play a crucial role in regulating disease resistance in model plants. However, their regulatory mechanisms of disease resistance in non-model plants, particularly in postharvest fruits, remain largely unknown. In this study, we observed that PpMYC2 expression was up-regulated in peach fruit following infection by Monilinia fructicola, while the expressions of PpJAM2/3 were down-regulated. Furthermore, we found that PpMYC2 positively regulated the resistance against M. fructicola, whereas PpJAM2/3 negatively regulated it. Through a combined DNA affinity purification and RNA sequencing analysis for PpMYC2, we identified lignin synthesis genes (PpPAL1, PpC4H, Pp4CL1, PpCSE and PpCCoAOMT1) as candidate target genes. Subsequent assays, including dual-lucifera","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-27T21:12:48.071Z","creation":"2026-04-08T01:50:35.616Z"},"accession":"S-EPMC12392935","cross_references":{"pubmed":["40468145"],"doi":["10.1111/pbi.70177"]}}