{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Oliveira PN"],"funding":["Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["3540-3560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12392944"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["The Anaphase-Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that plays a crucial role in ubiquitin-dependent proteolysis of key cell cycle regulators, which is completed by the 26S proteasome. Previously, SAMBA, a plant-specific regulator of the APC/C, was identified in Arabidopsis as a critical factor controlling organ size through the regulation of cell proliferation. Here, by assessing its role in the crop tomato (Solanum lycopersicum), we confirm that SAMBA is a conserved APC/C regulator in plants and shows additional roles, including the modulation of fruit shape and changes in sugar metabolism. Two slsamba genome-edited lines were produced and characterized, and showed delayed growth, reduced plant size, and altered fruit morphology, which were linked to changes in cel"],"journal":["Plant biotechnology journal"],"pubmed_title":["Modulating the activity of the APC/C regulator SISAMBA improves the sugar and antioxidant content of tomato fruits."],"pmcid":["PMC12392944"],"funding_grant_id":["2021/03212-5","2017/10333‐8","2020/00888‐5","2021/06611-8","2020/00888-5","2021/06611‐8","2021/03212‐5","2017/10333-8","2023/13107‐0","2023/13107-0"],"pubmed_authors":["Mauxion JP","Saleme MLS","Fernie AR","Zhu F","Martins MCM","Chang AI","Gonzalez N","Garcia SS","de Oliveira PN","Rosado-Souza L","da Silva LFC","Eloy NB","Ferreira PB","De Beukelaer H","Bollier N","Vandepoele K","Goossens A","de Souza LP","Pino LE","Peres LEP"],"additional_accession":[]},"is_claimable":false,"name":"Modulating the activity of the APC/C regulator SISAMBA improves the sugar and antioxidant content of tomato fruits.","description":"The Anaphase-Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that plays a crucial role in ubiquitin-dependent proteolysis of key cell cycle regulators, which is completed by the 26S proteasome. Previously, SAMBA, a plant-specific regulator of the APC/C, was identified in Arabidopsis as a critical factor controlling organ size through the regulation of cell proliferation. Here, by assessing its role in the crop tomato (Solanum lycopersicum), we confirm that SAMBA is a conserved APC/C regulator in plants and shows additional roles, including the modulation of fruit shape and changes in sugar metabolism. Two slsamba genome-edited lines were produced and characterized, and showed delayed growth, reduced plant size, and altered fruit morphology, which were linked to changes in cel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-27T21:12:37.538Z","creation":"2026-04-08T01:50:31.587Z"},"accession":"S-EPMC12392944","cross_references":{"pubmed":["40483582"],"doi":["10.1111/pbi.70149"]}}