biostudies-literatureUnknownDzinalija NNIMH NIH HHSWellcome Trust<h4>Objective</h4>Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during executive control, we conducted a mega-analysis in the ENIGMA-OCD consortium pooling individual participant data from 475 individuals with OCD and 345 healthy controls across 15 fMRI tasks collected worldwide.<h4>Methods</h4>Individual participant data was uniformly processed using HALFpipe to construct voxelwise statistical images of executive control and task load contrasts. Parameter estimates extracted from regions of interest were entered into multilevel Bayesian models to examine regional and whole-brain effects of diagnosis, and, within OCD, the bioRxiv : the preprint server for biology2025.08.20.671231https://www.ebi.ac.uk/biostudies/studies/S-EPMC12393554biostudies-literatureExecutive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium.PMC12393554R01 MH138569500236/Z/11/ZLochner CZhao YJHuijser CVai BMartinez-Zalacain IVriend CKwon JSKim MMenchon JMNarayanaswamy JCLiu WCalesella FStewart SEVenkatasubramanian GSoriano-Mas Cvan der Werf YDIvanov IDzinalija NBenedetti FPostma TSKathmann NGrutzmann RHagen KHansen BBalachander SVeltman DJSimpson HBThorsen ALvan den Heuvel OAJaspers-Fayer FReddy YCJIpser JWaller LOlivier ISFitzsimmons SMDDHeinzel SENIGMA-OCD consortiumStein DJThomopoulos SIde Joode NTThompson PMVeer IMVoon VfalseExecutive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium.<h4>Objective</h4>Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during executive control, we conducted a mega-analysis in the ENIGMA-OCD consortium pooling individual participant data from 475 individuals with OCD and 345 healthy controls across 15 fMRI tasks collected worldwide.<h4>Methods</h4>Individual participant data was uniformly processed using HALFpipe to construct voxelwise statistical images of executive control and task load contrasts. Parameter estimates extracted from regions of interest were entered into multilevel Bayesian models to examine regional and whole-brain effects of diagnosis, and, within OCD, the 2025-01-01T00:00:00Z2025 Aug2026-04-08T16:14:41.372Z2026-04-08T06:12:05.307ZS-EPMC123935544089459410.1101/2025.08.20.671231