biostudies-literatureLangan LMNational Institute of Environmental Health SciencesNIEHS NIH HHSBaylor UniversityNational Institutes of HealthGlasscock Fund for Excellence in Environmental ScienceNIH HHSNational Science Foundation2580-2598https://www.ebi.ac.uk/biostudies/studies/S-EPMC12394885biostudies-literatureUnknown44(9)Due to its increasing affordability and efforts to understand transcriptional responses of organisms to biotic and abiotic stimuli, transcriptomics has become an important tool with significant impact on toxicological investigations and hazard and risk assessments, especially during development and application of new approach methodologies (NAMs). Data generated using transcriptomic methodologies have directly informed adverse outcome pathway frameworks, chemical and biological read across, and aided in the identification of points of departure. Using data reporting frameworks for transcriptomics data offers improved transparency and reproducibility of research and an opportunity to identify barriers to adoption of these NAMs, especially in environmental toxicology and ecotoxicology with aEnvironmental toxicology and chemistryExperimental reporting of fish transcriptomic responses in environmental toxicology and ecotoxicology.PMC12394885CBET-2042060P01 ES0289421P01ES028942Shmaitelly YScarlett KCole ARLovin LO'Brien MELangan LMWronski ARBrooks BWBaettig CGfalseExperimental reporting of fish transcriptomic responses in environmental toxicology and ecotoxicology.Due to its increasing affordability and efforts to understand transcriptional responses of organisms to biotic and abiotic stimuli, transcriptomics has become an important tool with significant impact on toxicological investigations and hazard and risk assessments, especially during development and application of new approach methodologies (NAMs). Data generated using transcriptomic methodologies have directly informed adverse outcome pathway frameworks, chemical and biological read across, and aided in the identification of points of departure. Using data reporting frameworks for transcriptomics data offers improved transparency and reproducibility of research and an opportunity to identify barriers to adoption of these NAMs, especially in environmental toxicology and ecotoxicology with a2025-01-01T00:00:00Z2025 Sep2026-05-29T03:18:28.815Z2026-05-29T03:12:07.625ZS-EPMC123948853996513810.1093/etojnl/vgae077