{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopez-Lee C"],"funding":["NEI NIH HHS","NIA NIH HHS","NIAMS NIH HHS"],"pagination":["eadk7844"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12396121"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["386(6725)"],"pubmed_abstract":["Alzheimer's disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex chromosomes and gonads in demyelination and AD. In a mouse model of demyelination, we identified the roles of sex chromosomes and gonads in modifying microglia and oligodendrocyte responses before and after myelin loss. In an AD-related mouse model expressing APOE4, XY sex chromosomes heightened interferon (IFN) response and tau-induced demyelination. The X-linked gene, Toll-like receptor 7 (<i>Tlr7</i>), regulated sex-specific IFN response to myelin. Deletion of <i>Tlr7</i> dampened sex differences while protecting against demyelination. Administering TLR7 inhibitor mitigated tau-induced moto"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["&lt;i&gt;Tlr7&lt;/i&gt; drives sex differences in age- and Alzheimer's disease-related demyelination."],"pmcid":["PMC12396121"],"funding_grant_id":["R01 AG068325","R01 AG072758","RF1 AG068325","R01 AG064239","RF1 AG079176","R01 AG074541","R01 AR074541","R01 EY033353","R01 AG054214"],"pubmed_authors":["Lopez-Lee C","Yu F","Foxe NR","Liddelow SA","Chen H","Carling GK","Torres ER","Zhu D","Dubal DB","Norman K","Ijaz L","Zhu J","Sinha SC","Ye P","Kim RD","Gan L","Fan L","Luo W","Kodama L","Wong MY"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Tlr7&lt;/i&gt; drives sex differences in age- and Alzheimer's disease-related demyelination.","description":"Alzheimer's disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex chromosomes and gonads in demyelination and AD. In a mouse model of demyelination, we identified the roles of sex chromosomes and gonads in modifying microglia and oligodendrocyte responses before and after myelin loss. In an AD-related mouse model expressing APOE4, XY sex chromosomes heightened interferon (IFN) response and tau-induced demyelination. The X-linked gene, Toll-like receptor 7 (<i>Tlr7</i>), regulated sex-specific IFN response to myelin. Deletion of <i>Tlr7</i> dampened sex differences while protecting against demyelination. Administering TLR7 inhibitor mitigated tau-induced moto","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-05-27T21:10:45.474Z","creation":"2026-04-08T01:50:48.349Z"},"accession":"S-EPMC12396121","cross_references":{"pubmed":["39607927"],"doi":["10.1126/science.adk7844"]}}