{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Athertya JS"],"funding":["VA Clinical Science Research & Development Service","NIA NIH HHS","National Institutes of Health","NIH HHS","CSRD VA"],"pagination":["e70029"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12396502"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(1)"],"pubmed_abstract":["<h4>Background and purpose</h4>This study aims to assess the potential of ultrashort echo time imaging-based magnetization transfer ratio (UTE-MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open-field low-intensity blast (LIB) injury model.<h4>Methods</h4>This study included 30 male C57BL/6 mice, approximately 8 weeks old, sourced from Jackson Laboratories in Bar Harbor, ME, and conducted under institutional guidelines. The mice were divided into the mTBI group (n = 15) and the sham control group (n = 15). All animal experiments followed the approved protocols for the Care and Use of Laboratory Animals and Animal Research. The mTBI group underwent the open-field LIB injury. Behavioral tests were conducted to assess motor activity and anxiety-li"],"journal":["Journal of neuroimaging : official journal of the American Society of Neuroimaging"],"pubmed_title":["Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury."],"pmcid":["PMC12396502"],"funding_grant_id":["I01CX002211","RF1 AG075717 F32AG082458","RF1 AG075717","I01 CX002211","F32 AG082458"],"pubmed_authors":["Johnson CE","Moazamian D","Athertya JS","Chang EY","Tang Q","Cui J","Ma Y","Gu Z","Du J","Cheng X"],"additional_accession":[]},"is_claimable":false,"name":"Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury.","description":"<h4>Background and purpose</h4>This study aims to assess the potential of ultrashort echo time imaging-based magnetization transfer ratio (UTE-MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open-field low-intensity blast (LIB) injury model.<h4>Methods</h4>This study included 30 male C57BL/6 mice, approximately 8 weeks old, sourced from Jackson Laboratories in Bar Harbor, ME, and conducted under institutional guidelines. The mice were divided into the mTBI group (n = 15) and the sham control group (n = 15). All animal experiments followed the approved protocols for the Care and Use of Laboratory Animals and Animal Research. The mTBI group underwent the open-field LIB injury. Behavioral tests were conducted to assess motor activity and anxiety-li","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan-Feb","modification":"2026-05-27T03:17:43.408Z","creation":"2026-05-27T03:11:47.634Z"},"accession":"S-EPMC12396502","cross_references":{"pubmed":["39994838"],"doi":["10.1111/jon.70029"]}}