biostudies-literatureAthertya JSVA Clinical Science Research & Development ServiceNIA NIH HHSNational Institutes of HealthNIH HHSCSRD VAe70029https://www.ebi.ac.uk/biostudies/studies/S-EPMC12396502biostudies-literatureUnknown35(1)<h4>Background and purpose</h4>This study aims to assess the potential of ultrashort echo time imaging-based magnetization transfer ratio (UTE-MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open-field low-intensity blast (LIB) injury model.<h4>Methods</h4>This study included 30 male C57BL/6 mice, approximately 8 weeks old, sourced from Jackson Laboratories in Bar Harbor, ME, and conducted under institutional guidelines. The mice were divided into the mTBI group (n = 15) and the sham control group (n = 15). All animal experiments followed the approved protocols for the Care and Use of Laboratory Animals and Animal Research. The mTBI group underwent the open-field LIB injury. Behavioral tests were conducted to assess motor activity and anxiety-liJournal of neuroimaging : official journal of the American Society of NeuroimagingMyelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury.PMC12396502I01CX002211RF1 AG075717 F32AG082458RF1 AG075717I01 CX002211F32 AG082458Johnson CEMoazamian DAthertya JSChang EYTang QCui JMa YGu ZDu JCheng XfalseMyelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury.<h4>Background and purpose</h4>This study aims to assess the potential of ultrashort echo time imaging-based magnetization transfer ratio (UTE-MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open-field low-intensity blast (LIB) injury model.<h4>Methods</h4>This study included 30 male C57BL/6 mice, approximately 8 weeks old, sourced from Jackson Laboratories in Bar Harbor, ME, and conducted under institutional guidelines. The mice were divided into the mTBI group (n = 15) and the sham control group (n = 15). All animal experiments followed the approved protocols for the Care and Use of Laboratory Animals and Animal Research. The mTBI group underwent the open-field LIB injury. Behavioral tests were conducted to assess motor activity and anxiety-li2025-01-01T00:00:00Z2025 Jan-Feb2026-05-27T03:17:43.408Z2026-05-27T03:11:47.634ZS-EPMC123965023999483810.1111/jon.70029