biostudies-literatureUnknown47(4)Mukhopadhyay PNational Institute On Alcohol Abuse and AlcoholismThe pathology of cardiovascular aging is complex, involving mitochondrial dysfunction, oxidative and nitrative stress, oxidative DNA injury, impaired lipid metabolism, cell death, senescence, and chronic inflammation. These processes lead to remodeling and structural changes in the cardiovascular system, resulting in a progressive decline in cardiovascular reserve capacity and health, and an increased risk of diseases and mortality. Excessive alcohol consumption exacerbates these risks by promoting hypertension, stroke, arrhythmias, coronary artery disease, cardiomyopathy, and sudden cardiac death, yet the effects of chronic alcohol consumption on cardiovascular aging remain unclear. Herein, we explored the impact of a 6-month 5% Lieber-DeCarli alcohol diet in young (3 months old) and aginGeroScience5881-5901https://www.ebi.ac.uk/biostudies/studies/S-EPMC12397455biostudies-literatureChronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity.PMC12397455Pacher PHasko GYokus BMukhopadhyay PPaes-Leme BBatkai SUngvari ZfalseChronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity.The pathology of cardiovascular aging is complex, involving mitochondrial dysfunction, oxidative and nitrative stress, oxidative DNA injury, impaired lipid metabolism, cell death, senescence, and chronic inflammation. These processes lead to remodeling and structural changes in the cardiovascular system, resulting in a progressive decline in cardiovascular reserve capacity and health, and an increased risk of diseases and mortality. Excessive alcohol consumption exacerbates these risks by promoting hypertension, stroke, arrhythmias, coronary artery disease, cardiomyopathy, and sudden cardiac death, yet the effects of chronic alcohol consumption on cardiovascular aging remain unclear. Herein, we explored the impact of a 6-month 5% Lieber-DeCarli alcohol diet in young (3 months old) and agin2025-01-01T00:00:00Z2025 Aug2026-05-27T21:10:04.38Z2026-04-08T01:50:29.518ZS-EPMC123974554011169910.1007/s11357-025-01613-w