biostudies-literatureUnknown15(9)Xue XQ<h4>Background</h4>Lymphovascular invasion (LVI) is a critical factor in the lymphatic spread of tumor cells, and is closely associated with local recurrence and distant metastasis in gastric cancer. The study aimed to evaluate the correlation and predictive value of preoperative total lesion glycolysis (TLG) in patients with primary gastric cancer as measured by a combination of ¹⁸F-labeled fluoro-2-deoxyglucose (¹⁸F-FDG) positron emission tomography (PET) and computed tomography (CT) for LVI.<h4>Methods</h4>A retrospective analysis of the demographic and ¹⁸F-FDG PET/CT data of 177 patients with gastric cancer diagnosed by postoperative pathology at The Third Affiliated Hospital of Soochow University between January 2014 and August 2021 was conducted. The Quantitative imaging in medicine and surgery7738-7748https://www.ebi.ac.uk/biostudies/studies/S-EPMC12397669biostudies-literatureThe correlation between preoperative total lesion glycolysis and lymphovascular invasion based on &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT and its predictive value in primary gastric cancer: a cross-sectional study.PMC12397669Xue XQWang YTLi XFShi XfalseThe correlation between preoperative total lesion glycolysis and lymphovascular invasion based on &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT and its predictive value in primary gastric cancer: a cross-sectional study.<h4>Background</h4>Lymphovascular invasion (LVI) is a critical factor in the lymphatic spread of tumor cells, and is closely associated with local recurrence and distant metastasis in gastric cancer. The study aimed to evaluate the correlation and predictive value of preoperative total lesion glycolysis (TLG) in patients with primary gastric cancer as measured by a combination of ¹⁸F-labeled fluoro-2-deoxyglucose (¹⁸F-FDG) positron emission tomography (PET) and computed tomography (CT) for LVI.<h4>Methods</h4>A retrospective analysis of the demographic and ¹⁸F-FDG PET/CT data of 177 patients with gastric cancer diagnosed by postoperative pathology at The Third Affiliated Hospital of Soochow University between January 2014 and August 2021 was conducted. The 2025-01-01T00:00:00Z2025 Sep2026-05-29T17:20:02.613Z2026-04-08T05:30:10.034ZS-EPMC123976694089356110.21037/qims-2025-644