biostudies-literatureKarmakar IScience and Engineering Research BoardNational Chung-Hsing UniversityNational Science and Technology CouncilMinistry of Education, Taiwan12205-12215https://www.ebi.ac.uk/biostudies/studies/S-EPMC12400415biostudies-literatureUnknown90(34)We report a robust and eco-conscious electrosynthetic protocol for efficiently constructing structurally diverse and biologically relevant dibenzoselenophenes. This transformation proceeds <i>via</i> electrochemical intramolecular C-H activation of bis(biaryl) diselenides, employing LiClO₄ as a green electrolyte and tetrabutylammonium bromide as an additive, conducted in DMSO at 70 °C under a constant current of 10 mA using Pt/Pt electrodes. The newly developed method offers several notable advantages, including mild and energy-efficient conditions, transition-metal-free catalysis, short reaction times, high to excellent yields, broad substrate tolerance, scalability to gram-scale synthesis, operational simplicity, and environmental friendliness.The Journal of organic chemistrySite-Selective Electrochemical Intramolecular C(sp&lt;sup&gt;2&lt;/sup&gt;)-H Selenylation for Dibenzoselenophene Synthesis.PMC12400415113-2113-M-005-014Jian YXCheng WLKarmakar IBai RChen YHLee CFfalseSite-Selective Electrochemical Intramolecular C(sp&lt;sup&gt;2&lt;/sup&gt;)-H Selenylation for Dibenzoselenophene Synthesis.We report a robust and eco-conscious electrosynthetic protocol for efficiently constructing structurally diverse and biologically relevant dibenzoselenophenes. This transformation proceeds <i>via</i> electrochemical intramolecular C-H activation of bis(biaryl) diselenides, employing LiClO₄ as a green electrolyte and tetrabutylammonium bromide as an additive, conducted in DMSO at 70 °C under a constant current of 10 mA using Pt/Pt electrodes. The newly developed method offers several notable advantages, including mild and energy-efficient conditions, transition-metal-free catalysis, short reaction times, high to excellent yields, broad substrate tolerance, scalability to gram-scale synthesis, operational simplicity, and environmental friendliness.2025-01-01T00:00:00Z2025 Aug2026-05-29T11:35:45.242Z2026-04-08T04:26:09.349ZS-EPMC124004154082517610.1021/acs.joc.5c01600