{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Malloy DC"],"funding":["HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","Pennsylvania Department of Health (PA DOH)","Craig H. Neilsen Foundation (CHNF)"],"pagination":["4845-4865"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12400786"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["603(17)"],"pubmed_abstract":["Transcutaneous spinal cord stimulation (tSCS) has become an increasingly popular and effective research intervention for functional recovery after spinal cord injury (SCI). Despite its surge in application for clinical investigations, there is a current lack of systematic approaches to investigate the optimal design of electrical stimulation protocols for a desired outcome. Important parameters that can affect the outcome are stimulation frequency and intensity. Previous work in humans and rodents have identified tSCS as a promising strategy to reduce spasticity and hyperreflexia after SCI. However, the stimulation intensities used in these studies vary widely and it remains unknown whether sub- or supra-motor threshold stimulation intensity is preferable for restoring spinal inhibition an"],"journal":["The Journal of physiology"],"pubmed_title":["Transcutaneous spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat."],"pmcid":["PMC12400786"],"funding_grant_id":["PA","647897","NS119475"],"pubmed_authors":["Malloy DC","Bilchak JN","Cote MP"],"additional_accession":[]},"is_claimable":false,"name":"Transcutaneous spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat.","description":"Transcutaneous spinal cord stimulation (tSCS) has become an increasingly popular and effective research intervention for functional recovery after spinal cord injury (SCI). Despite its surge in application for clinical investigations, there is a current lack of systematic approaches to investigate the optimal design of electrical stimulation protocols for a desired outcome. Important parameters that can affect the outcome are stimulation frequency and intensity. Previous work in humans and rodents have identified tSCS as a promising strategy to reduce spasticity and hyperreflexia after SCI. However, the stimulation intensities used in these studies vary widely and it remains unknown whether sub- or supra-motor threshold stimulation intensity is preferable for restoring spinal inhibition an","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T11:35:18.429Z","creation":"2026-04-08T04:30:47.714Z"},"accession":"S-EPMC12400786","cross_references":{"pubmed":["40785043"],"doi":["10.1113/JP287100"]}}