biostudies-literatureUnknown12Nie CQ fever, caused by <i>Coxiella burnetii</i> (Q fever <i>rickettsiae</i>), is a zoonotic disease with a natural reservoir and has been reported in many countries and regions. Its clinical presentation is non-specific and easily confused with other infectious or non-infectious diseases. Conventional diagnostic methods, such as respiratory specimen culture, often fail to yield conclusive results, increasing the risk of misdiagnosis. This case involves a 78-year-old male patient from Zhejiang Province, China, who presented with fever as the primary complaint and developed severe pneumonia. The diagnosis of H1N1 influenza co-infection with Coxiella burnetii was confirmed by bronchoalveolar lavage fluid targeted high-throughput sequencing (tNGS). Following antiviral treatment with Maraviroc and Frontiers in medicine1626115https://www.ebi.ac.uk/biostudies/studies/S-EPMC12401012biostudies-literatureOmadacycline in the treatment of severe Q fever pneumonia during an influenza epidemic: a case report with literature review.PMC12401012Nie CHu SYu MZhu YQian FJiang QZhu XZhong XZhou HZhao XfalseOmadacycline in the treatment of severe Q fever pneumonia during an influenza epidemic: a case report with literature review.Q fever, caused by <i>Coxiella burnetii</i> (Q fever <i>rickettsiae</i>), is a zoonotic disease with a natural reservoir and has been reported in many countries and regions. Its clinical presentation is non-specific and easily confused with other infectious or non-infectious diseases. Conventional diagnostic methods, such as respiratory specimen culture, often fail to yield conclusive results, increasing the risk of misdiagnosis. This case involves a 78-year-old male patient from Zhejiang Province, China, who presented with fever as the primary complaint and developed severe pneumonia. The diagnosis of H1N1 influenza co-infection with Coxiella burnetii was confirmed by bronchoalveolar lavage fluid targeted high-throughput sequencing (tNGS). Following antiviral treatment with Maraviroc and 2025-01-01T00:00:00Z20252026-05-29T22:10:00.996Z2026-05-18T03:07:09.743ZS-EPMC124010124090152210.3389/fmed.2025.1626115