{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Chen Y"],"pubmed_abstract":["<h4>Background</h4>Lung adenocarcinoma (LUAD) is one of the most prevalent types of lung cancer globally; it is characterized by high incidence and mortality rates and contributes to over 1.8 million deaths annually. PSMB7, a crucial component of the 20S proteasome involved in protein degradation and antigen presentation, has been implicated in various cancers; however, its specific function in LUAD remains inadequately explored.<h4>Methods</h4>This research aimed to investigate the expression of PSMB7 in LUAD and its clinical significance using real-time quantitative PCR, immunohistochemistry, differential expression analysis, pathway enrichment analysis, immune cell infiltration, and DNA methylation.<h4>Results</h4>PSMB7 expression levels in LUAD tissues were considerably higher than tho"],"journal":["PeerJ"],"pagination":["e19958"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12401020"],"repository":["biostudies-literature"],"pubmed_title":["Identification and validation of PSMB7 as a novel biomarker for prognosis and immune infiltrates of lung adenocarcinoma."],"pmcid":["PMC12401020"],"pubmed_authors":["Zhao L","Ran X","Ao J","Xiao H","Chen Y","Zhu G","Fu P"],"additional_accession":[]},"is_claimable":false,"name":"Identification and validation of PSMB7 as a novel biomarker for prognosis and immune infiltrates of lung adenocarcinoma.","description":"<h4>Background</h4>Lung adenocarcinoma (LUAD) is one of the most prevalent types of lung cancer globally; it is characterized by high incidence and mortality rates and contributes to over 1.8 million deaths annually. PSMB7, a crucial component of the 20S proteasome involved in protein degradation and antigen presentation, has been implicated in various cancers; however, its specific function in LUAD remains inadequately explored.<h4>Methods</h4>This research aimed to investigate the expression of PSMB7 in LUAD and its clinical significance using real-time quantitative PCR, immunohistochemistry, differential expression analysis, pathway enrichment analysis, immune cell infiltration, and DNA methylation.<h4>Results</h4>PSMB7 expression levels in LUAD tissues were considerably higher than tho","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-29T16:30:17.642Z","creation":"2026-04-08T05:26:07.854Z"},"accession":"S-EPMC12401020","cross_references":{"pubmed":["40900751"],"doi":["10.7717/peerj.19958"]}}