biostudies-literatureUnknown13Chen Y<h4>Background</h4>Lung adenocarcinoma (LUAD) is one of the most prevalent types of lung cancer globally; it is characterized by high incidence and mortality rates and contributes to over 1.8 million deaths annually. PSMB7, a crucial component of the 20S proteasome involved in protein degradation and antigen presentation, has been implicated in various cancers; however, its specific function in LUAD remains inadequately explored.<h4>Methods</h4>This research aimed to investigate the expression of PSMB7 in LUAD and its clinical significance using real-time quantitative PCR, immunohistochemistry, differential expression analysis, pathway enrichment analysis, immune cell infiltration, and DNA methylation.<h4>Results</h4>PSMB7 expression levels in LUAD tissues were considerably higher than thoPeerJe19958https://www.ebi.ac.uk/biostudies/studies/S-EPMC12401020biostudies-literatureIdentification and validation of PSMB7 as a novel biomarker for prognosis and immune infiltrates of lung adenocarcinoma.PMC12401020Zhao LRan XAo JXiao HChen YZhu GFu PfalseIdentification and validation of PSMB7 as a novel biomarker for prognosis and immune infiltrates of lung adenocarcinoma.<h4>Background</h4>Lung adenocarcinoma (LUAD) is one of the most prevalent types of lung cancer globally; it is characterized by high incidence and mortality rates and contributes to over 1.8 million deaths annually. PSMB7, a crucial component of the 20S proteasome involved in protein degradation and antigen presentation, has been implicated in various cancers; however, its specific function in LUAD remains inadequately explored.<h4>Methods</h4>This research aimed to investigate the expression of PSMB7 in LUAD and its clinical significance using real-time quantitative PCR, immunohistochemistry, differential expression analysis, pathway enrichment analysis, immune cell infiltration, and DNA methylation.<h4>Results</h4>PSMB7 expression levels in LUAD tissues were considerably higher than tho2025-01-01T00:00:00Z20252026-05-29T16:30:17.642Z2026-04-08T05:26:07.854ZS-EPMC124010204090075110.7717/peerj.19958