{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Guo Y"],"pubmed_abstract":["<h4>Objective</h4>Poorly differentiated thyroid cancer (PDTC) is a rare, heterogeneous carcinoma from follicular cells, characterized by poor differentiation, aggressive spread, and poor prognosis. Currently, there is no specific staging system for PDTC. This study aimed to develop a new TNM staging system tailored to PDTC for improved disease management.<h4>Methods</h4>A new TNM staging system was designed and internally validated using data from the US SEER database (2004-2016) on PDTC cases. External validation was performed using data from four major institutions in China. Prognostic factors influencing cancer-specific survival (CSS) were identified through Cox regression analyses. Patients were stratified into subgroups based on adjusted hazard ratios (AHRs), weighted by these prognos"],"journal":["Frontiers in endocrinology"],"pagination":["1586542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12401677"],"repository":["biostudies-literature"],"pubmed_title":["Development of a new TNM staging system for poorly differentiated thyroid carcinoma: a multicenter cohort study."],"pmcid":["PMC12401677"],"pubmed_authors":["Guo L","Zhong Q","Wu L","Guo Y","Zhuang S","Jia C","Xie L","Wang X","Yang A","Liu T","Peng J","Pang F"],"additional_accession":[]},"is_claimable":false,"name":"Development of a new TNM staging system for poorly differentiated thyroid carcinoma: a multicenter cohort study.","description":"<h4>Objective</h4>Poorly differentiated thyroid cancer (PDTC) is a rare, heterogeneous carcinoma from follicular cells, characterized by poor differentiation, aggressive spread, and poor prognosis. Currently, there is no specific staging system for PDTC. This study aimed to develop a new TNM staging system tailored to PDTC for improved disease management.<h4>Methods</h4>A new TNM staging system was designed and internally validated using data from the US SEER database (2004-2016) on PDTC cases. External validation was performed using data from four major institutions in China. Prognostic factors influencing cancer-specific survival (CSS) were identified through Cox regression analyses. Patients were stratified into subgroups based on adjusted hazard ratios (AHRs), weighted by these prognos","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-29T22:12:53.313Z","creation":"2026-05-18T03:07:33.459Z"},"accession":"S-EPMC12401677","cross_references":{"pubmed":["40904805"],"doi":["10.3389/fendo.2025.1586542"]}}