biostudies-literatureUnknown12Huang L<h4>Background</h4>A high Body Mass Index (BMI) is a key modifiable risk factor for cancer incidence. Therefore, it is essential to monitor the evolving trends and impact of cancer linked to high BMI and to formulate suitable strategies to address this issue. This study aims to analyze, from 1990 to 2021, the burden and temporal trends of cancer attributable to BMI as well as their impact on life expectancy, with major patterns highlighted by sex, socio-demographic index (SDI), and geographical region.<h4>Methods</h4>Utilizing data from the Global Burden of Disease Study 2021, which incorporates 328,938 data sources, we conducted a comprehensive analysis of cancer attributable to high BMI, specifically investigating mortality rates and disability-adjusted life years (DALYs) from 1990 to 20Frontiers in nutrition1641276https://www.ebi.ac.uk/biostudies/studies/S-EPMC12401690biostudies-literatureGlobal, regional, and national burden of high body-mass index-related cancers and associated preventable life expectancy loss from 1990 to 2021.PMC12401690Liang XWang DLi PHuang LfalseGlobal, regional, and national burden of high body-mass index-related cancers and associated preventable life expectancy loss from 1990 to 2021.<h4>Background</h4>A high Body Mass Index (BMI) is a key modifiable risk factor for cancer incidence. Therefore, it is essential to monitor the evolving trends and impact of cancer linked to high BMI and to formulate suitable strategies to address this issue. This study aims to analyze, from 1990 to 2021, the burden and temporal trends of cancer attributable to BMI as well as their impact on life expectancy, with major patterns highlighted by sex, socio-demographic index (SDI), and geographical region.<h4>Methods</h4>Utilizing data from the Global Burden of Disease Study 2021, which incorporates 328,938 data sources, we conducted a comprehensive analysis of cancer attributable to high BMI, specifically investigating mortality rates and disability-adjusted life years (DALYs) from 1990 to 202025-01-01T00:00:00Z20252026-05-29T22:12:59.903Z2026-05-18T03:07:34.714ZS-EPMC124016904090477810.3389/fnut.2025.1641276