{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhang X"],"pubmed_abstract":["<h4>Objective</h4>Air pollution is a major environmental risk to human health, with increasing evidence linking it to non-alcoholic fatty liver disease (NAFLD). However, findings remain inconsistent. This meta-analysis aimed to assess the relationship between air pollutants and the risk of NAFLD.<h4>Methods</h4>PubMed, Embase, and Web of Science were systematically searched for studies published up to March 20, 2025. A random effects model was used to estimate combined odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analysis, sensitivity analysis, funnel plots, and Egger's test were conducted.<h4>Results</h4>A total of 12 studies, including 49,549,903 participants (published between 2022 and 2024), were analyzed. For each 10 μg/m3 increase in pollutants, the ORs were 1.22 (1.16-1.29) for particulate matter with aerodynamic diameter ≤ 2.5 μm (PM<sub>2.5</sub>), 1.15 (0.95-1.40) for particulate matter between 2.5 and 10 μm in aerodynamic diameter (PM<sub>2.5 - 10</sub>), and 1.07 (1.01-1.13) for particulate matter with aerodynamic diameter ≤ 10 μm (PM<sub>10</sub>). For gaseous pollutants, the ORs were 1.45 (0.92-2.28) for sulfur dioxide (SO<sub>2</sub>) and 1.10 (1.06-1.14) for nitrogen dioxide (NO<sub>2</sub>). No notable connection emerged between ozone (O<sub>3</sub>) or carbon monoxide (CO) and NAFLD. Subgroup analysis revealed stronger associations for PM<sub>2.5</sub>, PM<sub>10</sub>, and NO<sub>2</sub> with NAFLD in developed countries, Europe, and cohort studies, compared to developing countries, Asia, and cross-sectional studies.<h4>Conclusion</h4>This analysis supports a positive relationship between air pollution and NAFLD risk. Geographic region and economic development appear to moderate this association.<h4>Systematic review registration</h4>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024594146, Identifier: CRD42024594146."],"journal":["Frontiers in public health"],"pagination":["1606959"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12401902"],"repository":["biostudies-literature"],"pubmed_title":["Association between air pollution and risk of non-alcoholic fatty liver disease: an updated meta-analysis."],"pmcid":["PMC12401902"],"pubmed_authors":["Yang X","Tan L","Li X","Ru S","Zhang X","Hu L","Chai Y"],"additional_accession":[]},"is_claimable":false,"name":"Association between air pollution and risk of non-alcoholic fatty liver disease: an updated meta-analysis.","description":"<h4>Objective</h4>Air pollution is a major environmental risk to human health, with increasing evidence linking it to non-alcoholic fatty liver disease (NAFLD). However, findings remain inconsistent. This meta-analysis aimed to assess the relationship between air pollutants and the risk of NAFLD.<h4>Methods</h4>PubMed, Embase, and Web of Science were systematically searched for studies published up to March 20, 2025. A random effects model was used to estimate combined odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analysis, sensitivity analysis, funnel plots, and Egger's test were conducted.<h4>Results</h4>A total of 12 studies, including 49,549,903 participants (published between 2022 and 2024), were analyzed. For each 10 μg/m3 increase in pollutants, the ORs were 1.22 (1.16-1.29) for particulate matter with aerodynamic diameter ≤ 2.5 μm (PM<sub>2.5</sub>), 1.15 (0.95-1.40) for particulate matter between 2.5 and 10 μm in aerodynamic diameter (PM<sub>2.5 - 10</sub>), and 1.07 (1.01-1.13) for particulate matter with aerodynamic diameter ≤ 10 μm (PM<sub>10</sub>). For gaseous pollutants, the ORs were 1.45 (0.92-2.28) for sulfur dioxide (SO<sub>2</sub>) and 1.10 (1.06-1.14) for nitrogen dioxide (NO<sub>2</sub>). No notable connection emerged between ozone (O<sub>3</sub>) or carbon monoxide (CO) and NAFLD. Subgroup analysis revealed stronger associations for PM<sub>2.5</sub>, PM<sub>10</sub>, and NO<sub>2</sub> with NAFLD in developed countries, Europe, and cohort studies, compared to developing countries, Asia, and cross-sectional studies.<h4>Conclusion</h4>This analysis supports a positive relationship between air pollution and NAFLD risk. Geographic region and economic development appear to moderate this association.<h4>Systematic review registration</h4>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024594146, Identifier: CRD42024594146.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-29T21:28:53.957Z","creation":"2026-04-08T06:02:02.963Z"},"accession":"S-EPMC12401902","cross_references":{"pubmed":["40904922"],"doi":["10.3389/fpubh.2025.1606959"]}}