biostudies-literatureUnknown40(10)Pitekova BComenius University in Bratislava<h4>Background</h4>Urinary tract infection (UTI) is a common bacterial infection in the pediatric population. Febrile urinary tract infection (fUTI) can lead to severe complications such as urosepsis as well as kidney scarring, chronic kidney disease, and systemic hypertension. Recent research supports the hypothesis that dysbiosis of the microbiome may play a role in the pathogenesis and development of fUTI in infants. Our main aim was to compare the shift in gut microbiota composition between children with the first fUTI and controls.<h4>Methods</h4>We conducted an observational study with 17 children with the first fUTI compared to 18 healthy controls. We performed analysis of the gastrointestinal microbiome and measurements of metabolites in stool and urine.<h4>Results</h4>In the gut mPediatric nephrology (Berlin, Germany)3145-3154https://www.ebi.ac.uk/biostudies/studies/S-EPMC12402013biostudies-literatureThe gut microbiome and metabolome in children with a first febrile urinary tract infection: a pilot study.PMC12402013Zieg JBaranovicova EKonopasek PPlanet PJPitekova BHric IGecz JBielik VfalseThe gut microbiome and metabolome in children with a first febrile urinary tract infection: a pilot study.<h4>Background</h4>Urinary tract infection (UTI) is a common bacterial infection in the pediatric population. Febrile urinary tract infection (fUTI) can lead to severe complications such as urosepsis as well as kidney scarring, chronic kidney disease, and systemic hypertension. Recent research supports the hypothesis that dysbiosis of the microbiome may play a role in the pathogenesis and development of fUTI in infants. Our main aim was to compare the shift in gut microbiota composition between children with the first fUTI and controls.<h4>Methods</h4>We conducted an observational study with 17 children with the first fUTI compared to 18 healthy controls. We performed analysis of the gastrointestinal microbiome and measurements of metabolites in stool and urine.<h4>Results</h4>In the gut m2025-01-01T00:00:00Z2025 Oct2026-04-08T15:33:24.029Z2026-04-08T05:02:21.106ZS-EPMC124020134036912610.1007/s00467-025-06782-6