{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(9)"],"submitter":["Bacha Z"],"pubmed_abstract":["<h4>Introduction</h4>Acute ischemic stroke (AIS) is the most common type of stroke, with increasing incidence and significant healthcare costs. Tenecteplase (TNK), a modified variant of tissue plasminogen activator (tPA), offers advantages such as a longer half-life and single-bolus administration. This meta-analysis evaluates the safety and efficacy of TNK compared to non-thrombolytic management in AIS to guide clinical decision-making.<h4>Methodology</h4>A comprehensive literature search across major databases identified randomized controlled trials (RCTs) comparing tenecteplase with non-thrombolytic care in ischemic stroke. Data extraction and bias assessment were conducted independently, using RoB 2.0 and the GRADE framework. Meta-analysis was performed using RevMan 5.4.1, applying ran"],"journal":["Brain and behavior"],"pagination":["e70791"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12402402"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials."],"pmcid":["PMC12402402"],"pubmed_authors":["Afridi A","Javed J","Iqbal A","Ahmed R","Khan MEW","Shahid S","Qasim M","Khattak F","Henna F","Bacha Z","Ali MA","Shah MA","Sheraz M"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.","description":"<h4>Introduction</h4>Acute ischemic stroke (AIS) is the most common type of stroke, with increasing incidence and significant healthcare costs. Tenecteplase (TNK), a modified variant of tissue plasminogen activator (tPA), offers advantages such as a longer half-life and single-bolus administration. This meta-analysis evaluates the safety and efficacy of TNK compared to non-thrombolytic management in AIS to guide clinical decision-making.<h4>Methodology</h4>A comprehensive literature search across major databases identified randomized controlled trials (RCTs) comparing tenecteplase with non-thrombolytic care in ischemic stroke. Data extraction and bias assessment were conducted independently, using RoB 2.0 and the GRADE framework. Meta-analysis was performed using RevMan 5.4.1, applying ran","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T15:13:24.457Z","creation":"2026-04-08T05:07:33.038Z"},"accession":"S-EPMC12402402","cross_references":{"pubmed":["40891051"],"doi":["10.1002/brb3.70791"]}}