biostudies-literatureUnknown15(9)Bacha Z<h4>Introduction</h4>Acute ischemic stroke (AIS) is the most common type of stroke, with increasing incidence and significant healthcare costs. Tenecteplase (TNK), a modified variant of tissue plasminogen activator (tPA), offers advantages such as a longer half-life and single-bolus administration. This meta-analysis evaluates the safety and efficacy of TNK compared to non-thrombolytic management in AIS to guide clinical decision-making.<h4>Methodology</h4>A comprehensive literature search across major databases identified randomized controlled trials (RCTs) comparing tenecteplase with non-thrombolytic care in ischemic stroke. Data extraction and bias assessment were conducted independently, using RoB 2.0 and the GRADE framework. Meta-analysis was performed using RevMan 5.4.1, applying ranBrain and behaviore70791https://www.ebi.ac.uk/biostudies/studies/S-EPMC12402402biostudies-literatureEfficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.PMC12402402Afridi AJaved JIqbal AAhmed RKhan MEWShahid SQasim MKhattak FHenna FBacha ZAli MAShah MASheraz MfalseEfficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.<h4>Introduction</h4>Acute ischemic stroke (AIS) is the most common type of stroke, with increasing incidence and significant healthcare costs. Tenecteplase (TNK), a modified variant of tissue plasminogen activator (tPA), offers advantages such as a longer half-life and single-bolus administration. This meta-analysis evaluates the safety and efficacy of TNK compared to non-thrombolytic management in AIS to guide clinical decision-making.<h4>Methodology</h4>A comprehensive literature search across major databases identified randomized controlled trials (RCTs) comparing tenecteplase with non-thrombolytic care in ischemic stroke. Data extraction and bias assessment were conducted independently, using RoB 2.0 and the GRADE framework. Meta-analysis was performed using RevMan 5.4.1, applying ran2025-01-01T00:00:00Z2025 Sep2026-05-29T15:13:24.457Z2026-04-08T05:07:33.038ZS-EPMC124024024089105110.1002/brb3.70791