{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Noel JP"],"funding":["NINDS NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","Wellcome Trust"],"pagination":["1519-1532"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12403184"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(7)"],"pubmed_abstract":["Computational psychiatry studies suggest that individuals with autism spectrum disorder (ASD) inflexibly update their expectations. Here we leveraged high-yield rodent psychophysics, extensive behavioral modeling and brain-wide single-cell extracellular recordings to assess whether mice with different genetic perturbations associated with ASD show this same computational anomaly, and if so, what neurophysiological features are shared across genotypes. Mice harboring mutations in Fmr1, Cntnap2 or Shank3B show a blunted update of priors during decision-making. Compared with mice that flexibly updated their priors, inflexible updating of priors was associated with a shift in the weighting of prior encoding from sensory to frontal cortices. Furthermore, frontal areas in mouse models of ASD sho"],"journal":["Nature neuroscience"],"pubmed_title":["A common computational and neural anomaly across mouse models of autism."],"pmcid":["PMC12403184"],"funding_grant_id":["216324","K99NS128075","R00 NS128075"],"pubmed_authors":["Dan Y","Bonacchi N","Gercek B","Mrsic-Flogel TD","Freitas-Silva L","Mainen ZF","Harris KD","International Brain Laboratory","Savin C","Benson J","Wells MJ","Paninski L","Hofer SB","Miska NJ","Chapuis GA","Dayan P","Witten IB","Schartner M","Acerbi L","Whiteway MR","Catarino JA","Balzani E","Krasniak C","Engel TA","Steinmetz NA","Rossant C","Hu F","Pouget A","Khanal A","Roth N","Birman D","Socha KZ","Carandini M","DeWitt EE","Noel JP","Faulkner M","Pan-Vazquez A","Svoboda K","Angelaki DE","Churchland AK","Huntenburg JM","Davatolhagh F","West SJ","Winter O","Angelaki D","Meijer GT","Fiete IR","Hausser M","Urai AE"],"additional_accession":[]},"is_claimable":false,"name":"A common computational and neural anomaly across mouse models of autism.","description":"Computational psychiatry studies suggest that individuals with autism spectrum disorder (ASD) inflexibly update their expectations. Here we leveraged high-yield rodent psychophysics, extensive behavioral modeling and brain-wide single-cell extracellular recordings to assess whether mice with different genetic perturbations associated with ASD show this same computational anomaly, and if so, what neurophysiological features are shared across genotypes. Mice harboring mutations in Fmr1, Cntnap2 or Shank3B show a blunted update of priors during decision-making. Compared with mice that flexibly updated their priors, inflexible updating of priors was associated with a shift in the weighting of prior encoding from sensory to frontal cortices. Furthermore, frontal areas in mouse models of ASD sho","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-29T15:12:03.486Z","creation":"2026-04-08T05:11:17.961Z"},"accession":"S-EPMC12403184","cross_references":{"pubmed":["40461847"],"doi":["10.1038/s41593-025-01965-8"]}}