{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Woods R"],"funding":["NCI NIH HHS"],"pagination":["3076-3084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12404152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(12)"],"pubmed_abstract":["<h4>Background</h4>We evaluate outcomes of SMARCB1-deficient sinonasal carcinomas in the largest single-institution study.<h4>Methods</h4>Retrospective cross-sectional study of patients with SMARCB1-deficient sinonasal carcinoma between 1998 and 2024. Disease-specific survival (DSS) and recurrence-free probability (RFP) at 1 and 5 years were measured by Kaplan-Meier method.<h4>Results</h4>There were 47 patients with a median age of 53. Initial pathological diagnosis was altered in 33%. Twelve (34%) patients received neoadjuvant chemotherapy, with one partial response. Curative surgical approach was undertaken in 73%. Definitive chemoradiation was administered in 20%. DSS at 1 and 5 years was 93% and 45%, respectively. RFP at 1 and 5 years was 73% and 33%, respectively. On multivariate anal"],"journal":["Head & neck"],"pubmed_title":["Outcomes of SMARCB1-deficient sinonasal carcinoma: Largest single-center cross-sectional study."],"pmcid":["PMC12404152"],"funding_grant_id":["P30 CA008748"],"pubmed_authors":["Lee N","Cohen M","Woods R","Ganly I","Shah J","Dunn L","Cracchiolo J","Fitzgerald C","Dogan S","Axiotakis L","Patel S","Adilbay D","Scholfield D","Pfister D"],"additional_accession":[]},"is_claimable":false,"name":"Outcomes of SMARCB1-deficient sinonasal carcinoma: Largest single-center cross-sectional study.","description":"<h4>Background</h4>We evaluate outcomes of SMARCB1-deficient sinonasal carcinomas in the largest single-institution study.<h4>Methods</h4>Retrospective cross-sectional study of patients with SMARCB1-deficient sinonasal carcinoma between 1998 and 2024. Disease-specific survival (DSS) and recurrence-free probability (RFP) at 1 and 5 years were measured by Kaplan-Meier method.<h4>Results</h4>There were 47 patients with a median age of 53. Initial pathological diagnosis was altered in 33%. Twelve (34%) patients received neoadjuvant chemotherapy, with one partial response. Curative surgical approach was undertaken in 73%. Definitive chemoradiation was administered in 20%. DSS at 1 and 5 years was 93% and 45%, respectively. RFP at 1 and 5 years was 73% and 33%, respectively. On multivariate anal","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-04-08T15:42:38.582Z","creation":"2026-04-08T05:12:01.251Z"},"accession":"S-EPMC12404152","cross_references":{"pubmed":["39044555"],"doi":["10.1002/hed.27859"]}}