biostudies-literatureWoods RNCI NIH HHS3076-3084https://www.ebi.ac.uk/biostudies/studies/S-EPMC12404152biostudies-literatureUnknown46(12)<h4>Background</h4>We evaluate outcomes of SMARCB1-deficient sinonasal carcinomas in the largest single-institution study.<h4>Methods</h4>Retrospective cross-sectional study of patients with SMARCB1-deficient sinonasal carcinoma between 1998 and 2024. Disease-specific survival (DSS) and recurrence-free probability (RFP) at 1 and 5 years were measured by Kaplan-Meier method.<h4>Results</h4>There were 47 patients with a median age of 53. Initial pathological diagnosis was altered in 33%. Twelve (34%) patients received neoadjuvant chemotherapy, with one partial response. Curative surgical approach was undertaken in 73%. Definitive chemoradiation was administered in 20%. DSS at 1 and 5 years was 93% and 45%, respectively. RFP at 1 and 5 years was 73% and 33%, respectively. On multivariate analHead & neckOutcomes of SMARCB1-deficient sinonasal carcinoma: Largest single-center cross-sectional study.PMC12404152P30 CA008748Lee NCohen MWoods RGanly IShah JDunn LCracchiolo JFitzgerald CDogan SAxiotakis LPatel SAdilbay DScholfield DPfister DfalseOutcomes of SMARCB1-deficient sinonasal carcinoma: Largest single-center cross-sectional study.<h4>Background</h4>We evaluate outcomes of SMARCB1-deficient sinonasal carcinomas in the largest single-institution study.<h4>Methods</h4>Retrospective cross-sectional study of patients with SMARCB1-deficient sinonasal carcinoma between 1998 and 2024. Disease-specific survival (DSS) and recurrence-free probability (RFP) at 1 and 5 years were measured by Kaplan-Meier method.<h4>Results</h4>There were 47 patients with a median age of 53. Initial pathological diagnosis was altered in 33%. Twelve (34%) patients received neoadjuvant chemotherapy, with one partial response. Curative surgical approach was undertaken in 73%. Definitive chemoradiation was administered in 20%. DSS at 1 and 5 years was 93% and 45%, respectively. RFP at 1 and 5 years was 73% and 33%, respectively. On multivariate anal2024-01-01T00:00:00Z2024 Dec2026-04-08T15:42:38.582Z2026-04-08T05:12:01.251ZS-EPMC124041523904455510.1002/hed.27859