{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tamayo LI"],"funding":["National Institute of Environmental Health Sciences","National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["e1011826"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12404487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(9)"],"pubmed_abstract":["<h4>Background</h4>In Bangladesh, > 50 million individuals are chronically exposed to inorganic arsenic (iAs) through drinking water, increasing risk for cancer and other iAs-related diseases. Previous studies show that individuals' ability to metabolize and eliminate iAs, and their risk of toxicity, is influenced by genetic variation in the AS3MT and FTCD gene regions.<h4>Methods</h4>To identify additional loci influencing arsenic metabolism, we used data from Bangladeshi individuals to conduct genome-wide association analyses of the relative abundances of arsenic species measured in both urine (n = 6,540) and blood (n = 976). These species include iAs, monomethylated arsenic (MMA) and dimethylated arsenic (DMA) species.<h4>Results</h4>In analyses of urine arsenic species, we identified a"],"journal":["PLoS genetics"],"pubmed_title":["Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans."],"pmcid":["PMC12404487"],"funding_grant_id":["P30 ES027792","R21 ES035491","R35 ES028379","R01 DK123285"],"pubmed_authors":["Davydiuk T","Islam T","Vander Griend D","Tong L","Kibriya MG","Chen L","Tamayo LI","Haque SE","Ahsan H","Gamble MV","Le XC","Jasmine F","Graziano J","Pierce BL"],"additional_accession":[]},"is_claimable":false,"name":"Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans.","description":"<h4>Background</h4>In Bangladesh, > 50 million individuals are chronically exposed to inorganic arsenic (iAs) through drinking water, increasing risk for cancer and other iAs-related diseases. Previous studies show that individuals' ability to metabolize and eliminate iAs, and their risk of toxicity, is influenced by genetic variation in the AS3MT and FTCD gene regions.<h4>Methods</h4>To identify additional loci influencing arsenic metabolism, we used data from Bangladeshi individuals to conduct genome-wide association analyses of the relative abundances of arsenic species measured in both urine (n = 6,540) and blood (n = 976). These species include iAs, monomethylated arsenic (MMA) and dimethylated arsenic (DMA) species.<h4>Results</h4>In analyses of urine arsenic species, we identified a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T17:33:24.285Z","creation":"2026-04-08T05:38:14.929Z"},"accession":"S-EPMC12404487","cross_references":{"pubmed":["40892834"],"doi":["10.1371/journal.pgen.1011826"]}}