biostudies-literatureTamayo LINational Institute of Environmental Health SciencesNational Institute of Diabetes and Digestive and Kidney Diseasese1011826https://www.ebi.ac.uk/biostudies/studies/S-EPMC12404487biostudies-literatureUnknown21(9)<h4>Background</h4>In Bangladesh, > 50 million individuals are chronically exposed to inorganic arsenic (iAs) through drinking water, increasing risk for cancer and other iAs-related diseases. Previous studies show that individuals' ability to metabolize and eliminate iAs, and their risk of toxicity, is influenced by genetic variation in the AS3MT and FTCD gene regions.<h4>Methods</h4>To identify additional loci influencing arsenic metabolism, we used data from Bangladeshi individuals to conduct genome-wide association analyses of the relative abundances of arsenic species measured in both urine (n = 6,540) and blood (n = 976). These species include iAs, monomethylated arsenic (MMA) and dimethylated arsenic (DMA) species.<h4>Results</h4>In analyses of urine arsenic species, we identified aPLoS geneticsGenetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans.PMC12404487P30 ES027792R21 ES035491R35 ES028379R01 DK123285Davydiuk TIslam TVander Griend DTong LKibriya MGChen LTamayo LIHaque SEAhsan HGamble MVLe XCJasmine FGraziano JPierce BLfalseGenetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans.<h4>Background</h4>In Bangladesh, > 50 million individuals are chronically exposed to inorganic arsenic (iAs) through drinking water, increasing risk for cancer and other iAs-related diseases. Previous studies show that individuals' ability to metabolize and eliminate iAs, and their risk of toxicity, is influenced by genetic variation in the AS3MT and FTCD gene regions.<h4>Methods</h4>To identify additional loci influencing arsenic metabolism, we used data from Bangladeshi individuals to conduct genome-wide association analyses of the relative abundances of arsenic species measured in both urine (n = 6,540) and blood (n = 976). These species include iAs, monomethylated arsenic (MMA) and dimethylated arsenic (DMA) species.<h4>Results</h4>In analyses of urine arsenic species, we identified a2025-01-01T00:00:00Z2025 Sep2026-05-29T17:33:24.285Z2026-04-08T05:38:14.929ZS-EPMC124044874089283410.1371/journal.pgen.1011826