{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Martinez-Garcia M"],"pubmed_abstract":["Microbes and their viruses drive central biogeochemical cycles on a global scale. Understanding the biology and ecology of virus-host interactions and their impact on ecosystems depends on our ability to develop tools that enable high-throughput screening of ecologically relevant, uncultured virus-host pairs. Viruses infecting Pelagibacterales, the predominant bacteria in surface oceans, have been studied through computational analyses and cultivation efforts. Here, we employ an accessible microfluidics and semi-permeable capsule (SPC) technology to investigate the uncultured pelagiphage vSAG 37-F6-host interactions since it is one of the most abundant and ubiquitous viruses in the marine virosphere. First, we validated this technology using cultured virus-host pairs. Then, marine single c"],"journal":["ISME communications"],"pagination":["ycaf123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12404659"],"repository":["biostudies-literature"],"pubmed_title":["Targeted genomic analysis of a predominant uncultured marine pelagiphage-host model via microfluidics and semipermeable capsule technology."],"pmcid":["PMC12404659"],"pubmed_authors":["Anton J","Perez-Martin L","Lluesma-Gomez M","Sanchez FS","Orphan V","Nadal-Molero F","Rubio-Portillo E","Martin-Cuadrado AB","Escolano-Vico A","Martinez-Garcia M"],"additional_accession":[]},"is_claimable":false,"name":"Targeted genomic analysis of a predominant uncultured marine pelagiphage-host model via microfluidics and semipermeable capsule technology.","description":"Microbes and their viruses drive central biogeochemical cycles on a global scale. Understanding the biology and ecology of virus-host interactions and their impact on ecosystems depends on our ability to develop tools that enable high-throughput screening of ecologically relevant, uncultured virus-host pairs. Viruses infecting Pelagibacterales, the predominant bacteria in surface oceans, have been studied through computational analyses and cultivation efforts. Here, we employ an accessible microfluidics and semi-permeable capsule (SPC) technology to investigate the uncultured pelagiphage vSAG 37-F6-host interactions since it is one of the most abundant and ubiquitous viruses in the marine virosphere. First, we validated this technology using cultured virus-host pairs. Then, marine single c","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-05-29T21:32:31.111Z","creation":"2026-04-08T06:03:19.323Z"},"accession":"S-EPMC12404659","cross_references":{"pubmed":["40904541"],"doi":["10.1093/ismeco/ycaf123"]}}