biostudies-literatureUnknown43(1)Ditonno F<h4>Purpose</h4>Radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) in solitary kidney patients is a rare and underreported scenario. This study aims to compare the outcomes of UTUC solitary kidney patients becoming anephric after RNU to those of patients undergoing kidney-sparing surgery (KSS).<h4>Methods</h4>Data from patients with a solitary kidney were retrieved from the ROBUUST 2.0 database, a global, multicenter registry containing data on patients who underwent curative surgery for UTUC. Baseline patient demographics, disease characteristics, and surgical features were compared between RNU and KSS. Kaplan-Meier methods were used to estimate recurrence-free survival (RFS), metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OWorld journal of urology534https://www.ebi.ac.uk/biostudies/studies/S-EPMC12405301biostudies-literatureRadical nephroureterectomy vs kidney sparing surgery for upper tract urothelial carcinoma in solitary kidney patients: a multi-institutional analysis of the ROBUUST 2.0 registry.PMC12405301Nativ OFMoghaddam FSSimone GTufano ACorrea AFWang LTuderti GSingla NWu ZBronimann SStephens AMehrazin RAbdollah FMargulis VEun DDBhanvadia RMeagher MFVeccia APorpiglia FDitonno FAmparore DAutorino RMari ALee RBignante GGhoreifi ADjaladat HRais-Bahrami SFerro MLambertini LDehghanmanshadi ADerweesh IHPerdona SGonzalgo MLAntonelli AEraky ABertolo RKinoshita HYoshida TPuri DMinervini ADe Cobelli OBen-David RCheccucci EPorter JGhodoussipour SSundaram CPContieri RSidhom DfalseRadical nephroureterectomy vs kidney sparing surgery for upper tract urothelial carcinoma in solitary kidney patients: a multi-institutional analysis of the ROBUUST 2.0 registry.<h4>Purpose</h4>Radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) in solitary kidney patients is a rare and underreported scenario. This study aims to compare the outcomes of UTUC solitary kidney patients becoming anephric after RNU to those of patients undergoing kidney-sparing surgery (KSS).<h4>Methods</h4>Data from patients with a solitary kidney were retrieved from the ROBUUST 2.0 database, a global, multicenter registry containing data on patients who underwent curative surgery for UTUC. Baseline patient demographics, disease characteristics, and surgical features were compared between RNU and KSS. Kaplan-Meier methods were used to estimate recurrence-free survival (RFS), metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (O2025-01-01T00:00:00Z2025 Sep2026-05-29T22:02:22.888Z2026-04-08T06:13:07.428ZS-EPMC124053014089789210.1007/s00345-025-05882-0