{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(9)"],"submitter":["Nieto PA"],"funding":["Seeding Inc. DBA Tiny Health"],"pubmed_abstract":["<h4>Background</h4>Infants born via Cesarean section (C-section) often have a distinct gut microbiome and higher risks of atopic and immune-related conditions than vaginally delivered infants. We evaluated whether a microbiome-based program could shift gut microbiome composition and improve microbiome-associated health outcomes in C-section born infants.<h4>Methods</h4>This open-label, randomized, controlled trial included full-term C-section-born infants aged 0-3 months, randomized to an intervention (n = 25) or control arm (n = 29). Over 6 months, the intervention arm received two microbiome reports, personalized recommendations based on their microbiome, educational materials, and coaching calls focused on microbiome health. Parents reported health conditions via surveys.<h4>Primary out"],"journal":["Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology"],"pagination":["e70182"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12405607"],"repository":["biostudies-literature"],"pubmed_title":["Improving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial."],"pmcid":["PMC12405607"],"pubmed_authors":["Yuan Q","Song E","Tan DS","Hoy CS","Orlandi A","Nieto PA","Trachsel J","Nakama C","Mueller NT","Soderborg TK","Mars RA","Sukhum KV","Goad D"],"additional_accession":[]},"is_claimable":false,"name":"Improving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.","description":"<h4>Background</h4>Infants born via Cesarean section (C-section) often have a distinct gut microbiome and higher risks of atopic and immune-related conditions than vaginally delivered infants. We evaluated whether a microbiome-based program could shift gut microbiome composition and improve microbiome-associated health outcomes in C-section born infants.<h4>Methods</h4>This open-label, randomized, controlled trial included full-term C-section-born infants aged 0-3 months, randomized to an intervention (n = 25) or control arm (n = 29). Over 6 months, the intervention arm received two microbiome reports, personalized recommendations based on their microbiome, educational materials, and coaching calls focused on microbiome health. Parents reported health conditions via surveys.<h4>Primary out","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T22:02:25.791Z","creation":"2026-04-08T06:13:09.904Z"},"accession":"S-EPMC12405607","cross_references":{"pubmed":["40898384"],"doi":["10.1111/pai.70182"]}}