biostudies-literatureUnknown36(9)Nieto PASeeding Inc. DBA Tiny Health<h4>Background</h4>Infants born via Cesarean section (C-section) often have a distinct gut microbiome and higher risks of atopic and immune-related conditions than vaginally delivered infants. We evaluated whether a microbiome-based program could shift gut microbiome composition and improve microbiome-associated health outcomes in C-section born infants.<h4>Methods</h4>This open-label, randomized, controlled trial included full-term C-section-born infants aged 0-3 months, randomized to an intervention (n = 25) or control arm (n = 29). Over 6 months, the intervention arm received two microbiome reports, personalized recommendations based on their microbiome, educational materials, and coaching calls focused on microbiome health. Parents reported health conditions via surveys.<h4>Primary outPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunologye70182https://www.ebi.ac.uk/biostudies/studies/S-EPMC12405607biostudies-literatureImproving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.PMC12405607Yuan QSong ETan DSHoy CSOrlandi ANieto PATrachsel JNakama CMueller NTSoderborg TKMars RASukhum KVGoad DfalseImproving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.<h4>Background</h4>Infants born via Cesarean section (C-section) often have a distinct gut microbiome and higher risks of atopic and immune-related conditions than vaginally delivered infants. We evaluated whether a microbiome-based program could shift gut microbiome composition and improve microbiome-associated health outcomes in C-section born infants.<h4>Methods</h4>This open-label, randomized, controlled trial included full-term C-section-born infants aged 0-3 months, randomized to an intervention (n = 25) or control arm (n = 29). Over 6 months, the intervention arm received two microbiome reports, personalized recommendations based on their microbiome, educational materials, and coaching calls focused on microbiome health. Parents reported health conditions via surveys.<h4>Primary out2025-01-01T00:00:00Z2025 Sep2026-05-29T22:02:25.791Z2026-04-08T06:13:09.904ZS-EPMC124056074089838410.1111/pai.70182