{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Park S"],"funding":["UCSD Neural Circuits Training","NINDS NIH HHS","NIH","Paul G. Allen Family Foundation","NIH HHS"],"pagination":["iyaf122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12406002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["231(1)"],"pubmed_abstract":["Neurons maintain their morphology over prolonged periods of adult life with limited regenerative capacity. Among the various factors that shape neuronal morphology, lipids function as membrane components, signaling molecules, and regulators of synaptic plasticity. Here, we tested genes involved in phospholipid biosynthesis and identified their roles in axon regrowth and maintenance. CEPT-2 and EPT-1 are enzymes catalyzing the final steps in the de novo phospholipid synthesis (Kennedy) pathway. Loss of function mutants of cept-2 or ept-1 show reduced axon regrowth and failure to maintain axon morphology. We demonstrate that CEPT-2 is required cell-autonomously to prevent age-related axonal morphology defects. We further investigated genetic interactions of cept-2 or ept-1 with dip-2, a cons"],"journal":["Genetics"],"pubmed_title":["Phospholipid biogenesis maintains neuronal integrity during aging and axon regeneration."],"pmcid":["PMC12406002"],"funding_grant_id":["R35 NS127314","R01 NS093588","R01NS093588","P40 OD010440","T32 NS007220","R35NS127314"],"pubmed_authors":["Chisholm AD","Jin Y","Park S"],"additional_accession":[]},"is_claimable":false,"name":"Phospholipid biogenesis maintains neuronal integrity during aging and axon regeneration.","description":"Neurons maintain their morphology over prolonged periods of adult life with limited regenerative capacity. Among the various factors that shape neuronal morphology, lipids function as membrane components, signaling molecules, and regulators of synaptic plasticity. Here, we tested genes involved in phospholipid biosynthesis and identified their roles in axon regrowth and maintenance. CEPT-2 and EPT-1 are enzymes catalyzing the final steps in the de novo phospholipid synthesis (Kennedy) pathway. Loss of function mutants of cept-2 or ept-1 show reduced axon regrowth and failure to maintain axon morphology. We demonstrate that CEPT-2 is required cell-autonomously to prevent age-related axonal morphology defects. We further investigated genetic interactions of cept-2 or ept-1 with dip-2, a cons","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-04-08T16:04:12.378Z","creation":"2026-04-08T05:59:18.997Z"},"accession":"S-EPMC12406002","cross_references":{"pubmed":["40557979"],"doi":["10.1093/genetics/iyaf122"]}}