biostudies-literatureUnknown16(38)Lu JChemodynamic therapy (CDT) is a promising treatment modality that utilizes highly toxic hydroxyl radicals (˙OH) to kill tumor cells in situ. However, real-time monitoring of drug distribution and therapeutic response remains a challenge, hindering the optimization of personalized treatment regimens. Here, we developed a glutathione (GSH)-responsive nanoreactor (FA-Mn NR), with integrated magnetic resonance imaging (MRI) functionality for self-enhanced CDT. The nanoreactor undergoes GSH-triggered Mn2+ release, which simultaneously functions as an MRI contrast agent and catalyzes hydrogen peroxide (H2O2) to produce additional ˙OH, thereby achieving synergistic CDT amplification. The study demonstrates a theranostic platform combining GSH-responsive imaChemical science17736-17743https://www.ebi.ac.uk/biostudies/studies/S-EPMC12406947biostudies-literatureGSH-responsive magnetic imaging for in situ monitoring of tumor chemodynamic therapy.PMC12406947Zhang WJiang ZLu JLi PTang BChen XWang HTang YfalseGSH-responsive magnetic imaging for in situ monitoring of tumor chemodynamic therapy.Chemodynamic therapy (CDT) is a promising treatment modality that utilizes highly toxic hydroxyl radicals (˙OH) to kill tumor cells in situ. However, real-time monitoring of drug distribution and therapeutic response remains a challenge, hindering the optimization of personalized treatment regimens. Here, we developed a glutathione (GSH)-responsive nanoreactor (FA-Mn NR), with integrated magnetic resonance imaging (MRI) functionality for self-enhanced CDT. The nanoreactor undergoes GSH-triggered Mn2+ release, which simultaneously functions as an MRI contrast agent and catalyzes hydrogen peroxide (H2O2) to produce additional ˙OH, thereby achieving synergistic CDT amplification. The study demonstrates a theranostic platform combining GSH-responsive ima2025-01-01T00:00:00Z2025 Oct2026-06-04T01:31:05.097Z2026-05-03T03:14:02.343ZS-EPMC124069474091014210.1039/d5sc04436g