{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Basgul C"],"funding":["NIGMS NIH HHS"],"pagination":["2124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12406975"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(2)"],"pubmed_abstract":["In this study, our goal was to assess the suitability of a polyether-ether-ketone (PEEK) and silicon nitride (Si<sub>3</sub>N<sub>4</sub>) polymer composite for antimicrobial three-dimensional (3D)-printed cervical cages. Generic cage designs (PEEK and 15 vol.% Si<sub>3</sub>N<sub>4</sub>-PEEK) were 3D-printed, including solid and porous cage designs. Cages were tested in static compression, compression shear, and torsion per ASTM F2077. For antibacterial testing, virgin and composite filament samples were inoculated with <i>Staphylococcus epidermidis</i> and <i>Escherichia coli</i>. <i>In vitro</i> cell testing was conducted using MC3T3-E1 mouse preosteoblasts, where cell proliferation, cumulative mineralization, and osteogenic activity were measured. The 3D-printed PEEK and Si<sub>3</sub"],"journal":["International journal of bioprinting"],"pubmed_title":["Exploring the mechanical strength, antimicrobial performance, and bioactivity of 3D-printed silicon nitride-PEEK composites in cervical spinal cages."],"pmcid":["PMC12406975"],"funding_grant_id":["R41 GM146268"],"pubmed_authors":["Hickok NJ","Basgul C","DeSantis P","Kurtz SM","Derr T","Bock RM"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the mechanical strength, antimicrobial performance, and bioactivity of 3D-printed silicon nitride-PEEK composites in cervical spinal cages.","description":"In this study, our goal was to assess the suitability of a polyether-ether-ketone (PEEK) and silicon nitride (Si<sub>3</sub>N<sub>4</sub>) polymer composite for antimicrobial three-dimensional (3D)-printed cervical cages. Generic cage designs (PEEK and 15 vol.% Si<sub>3</sub>N<sub>4</sub>-PEEK) were 3D-printed, including solid and porous cage designs. Cages were tested in static compression, compression shear, and torsion per ASTM F2077. For antibacterial testing, virgin and composite filament samples were inoculated with <i>Staphylococcus epidermidis</i> and <i>Escherichia coli</i>. <i>In vitro</i> cell testing was conducted using MC3T3-E1 mouse preosteoblasts, where cell proliferation, cumulative mineralization, and osteogenic activity were measured. The 3D-printed PEEK and Si<sub>3</sub","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-05-29T21:43:04.226Z","creation":"2026-04-08T06:05:50.322Z"},"accession":"S-EPMC12406975","cross_references":{"pubmed":["40909184"],"doi":["10.36922/ijb.2124"]}}