biostudies-literatureUnknown31(9)Nyan DCWe performed monkeypox virus genome sequencing on clinical samples from Liberia, yielding 5 clade IIa genomes. Our analysis found no evidence of sustained human-to-human transmission, suggesting independent zoonotic spillovers from a diverse viral lineage. Public health officials should continue monitoring and sequencing efforts to identify emerging monkeypox virus lineages.Emerging infectious diseases1848-1851https://www.ebi.ac.uk/biostudies/studies/S-EPMC12407201biostudies-literatureMonkeypox Virus Clade IIa Infections, Liberia, 2023-2024.PMC12407201Zufan SERenken CMehta MJaryan FMoses JSBerry IMKuhn JHCrozier IWorwa GNyan DCGilayeneh JSMDonzo KSHirsch SMcNay LKlim SEFreeman BMShobayo BIHensley LETaweh FCorvah ABfalseMonkeypox Virus Clade IIa Infections, Liberia, 2023-2024.We performed monkeypox virus genome sequencing on clinical samples from Liberia, yielding 5 clade IIa genomes. Our analysis found no evidence of sustained human-to-human transmission, suggesting independent zoonotic spillovers from a diverse viral lineage. Public health officials should continue monitoring and sequencing efforts to identify emerging monkeypox virus lineages.2025-01-01T00:00:00Z2025 Sep2026-05-29T21:35:00.809Z2026-04-08T06:06:14.615ZS-EPMC124072014076319410.3201/eid3109.250271