{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stopsack KH"],"funding":["National Cancer Institute (NCI)","Prostate Cancer Foundation (PCF)","National Cancer Institute","NCI NIH HHS","Prostate Cancer Foundation"],"pagination":["122-129"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12407385"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(1)"],"pubmed_abstract":["<h4>Purpose</h4>Deleterious germline variants in certain DNA repair genes are risk factors for developing aggressive prostate cancer. The objective was to quantify their prognostic impact after prostate cancer diagnosis.<h4>Experimental design</h4>Men with prostate cancer, predominantly of European ancestry, were included from four cohorts with long-term follow-up. Pathogenic or likely pathogenic germline variants in 26 DNA repair genes were assessed in relation to metastasis-free survival in high-risk localized prostate cancer and to overall survival in metastatic castration-sensitive prostate cancer (mCSPC) and metastatic castration-resistant prostate cancer (mCRPC).<h4>Results</h4>Among 3,525 patients initially diagnosed with nonmetastatic prostate cancer, 2,594 had high-risk localized "],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer."],"pmcid":["PMC12407385"],"funding_grant_id":["P30CA06516","P50 CA092629","U01 CA167552","U01CA167552","P30 CA008748","P30 CA006516","P50CA092629","P30CA008748","P01 CA228696","18CHAL05","P01CA228696"],"pubmed_authors":["Vijai J","Berchuck JE","Mandelker D","Kantoff PW","Freeman DA","Offit K","Kemel Y","Morris MJ","Mucci LA","Stopsack KH","Pomerantz MM","Lee GM","Vasselman SE","Conry M","Penney KL","Abida W","Solit DB"],"additional_accession":[]},"is_claimable":false,"name":"Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer.","description":"<h4>Purpose</h4>Deleterious germline variants in certain DNA repair genes are risk factors for developing aggressive prostate cancer. The objective was to quantify their prognostic impact after prostate cancer diagnosis.<h4>Experimental design</h4>Men with prostate cancer, predominantly of European ancestry, were included from four cohorts with long-term follow-up. Pathogenic or likely pathogenic germline variants in 26 DNA repair genes were assessed in relation to metastasis-free survival in high-risk localized prostate cancer and to overall survival in metastatic castration-sensitive prostate cancer (mCSPC) and metastatic castration-resistant prostate cancer (mCRPC).<h4>Results</h4>Among 3,525 patients initially diagnosed with nonmetastatic prostate cancer, 2,594 had high-risk localized ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-05-29T21:38:37.72Z","creation":"2026-04-08T06:06:41.086Z"},"accession":"S-EPMC12407385","cross_references":{"pubmed":["39450704"],"doi":["10.1158/1078-0432.ccr-24-2483","10.1158/1078-0432.CCR-24-2483"]}}