{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["De Muyt A"],"funding":["NICHD NIH HHS"],"pubmed_abstract":["Meiotic crossovers are needed to produce genetically balanced gametes. In mammals, crossover formation is mediated by a conserved set of pro-crossover proteins via mechanisms that remain unclear. Here, we characterize a mammalian pro-crossover factor HEIP1. In mouse HEIP1 is essential for crossing over and fertility of both sexes. HEIP1 promotes crossing over by orchestrating the recruitment of other pro-crossover proteins, including the MutS<i>γ</i> complex (MSH4-MSH5) and E3 ligases (HEI10, RNF212, and RNF212B), that are required to mature crossover sites and recruit the crossover-specific resolution complex MutL<i>γ</i>. Moreover, HEIP1 directly interacts with HEI10, suggesting a direct role in controlling the recruitment of pro-crossover E3 ligases. During early stages of meiotic proph"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.08.25.672081"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12407729"],"repository":["biostudies-literature"],"pubmed_title":["HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis."],"pmcid":["PMC12407729"],"funding_grant_id":["R01 HD109322"],"pubmed_authors":["Lee S","Robert T","Mercier R","Borde V","De Muyt A","Khanal S","Adam C","Hunter N","Toe LD"],"additional_accession":[]},"is_claimable":false,"name":"HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis.","description":"Meiotic crossovers are needed to produce genetically balanced gametes. In mammals, crossover formation is mediated by a conserved set of pro-crossover proteins via mechanisms that remain unclear. Here, we characterize a mammalian pro-crossover factor HEIP1. In mouse HEIP1 is essential for crossing over and fertility of both sexes. HEIP1 promotes crossing over by orchestrating the recruitment of other pro-crossover proteins, including the MutS<i>γ</i> complex (MSH4-MSH5) and E3 ligases (HEI10, RNF212, and RNF212B), that are required to mature crossover sites and recruit the crossover-specific resolution complex MutL<i>γ</i>. Moreover, HEIP1 directly interacts with HEI10, suggesting a direct role in controlling the recruitment of pro-crossover E3 ligases. During early stages of meiotic proph","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-23T03:13:51.992Z","creation":"2026-04-23T03:10:02.789Z"},"accession":"S-EPMC12407729","cross_references":{"pubmed":["40909735"],"doi":["10.1101/2025.08.25.672081"]}}