{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Niekamp S"],"funding":["NIGMS NIH HHS"],"pubmed_abstract":["Opposing activities of conserved chromatin regulatory complexes, such as the Polycomb Repressive Complex 1 (PRC1) and the activating chromatin remodeler SWI/SNF play critical roles in regulating gene expression during development and differentiation. The mechanisms by which these complexes compete to regulate chromatin states remain poorly understood. We combine single-molecule analysis and genomic approaches in cultured cells to demonstrate that the condensate-forming properties of PRC1 play an important role in excluding SWI/SNF from chromatin. Consistently, PRC1 compositions with a higher propensity for condensate formation are more effective in preventing SWI/SNF binding. Conversely, SWI/SNF-bound chromatin significantly reduces PRC1 binding and subsequent condensate formation. Notably"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.08.25.672128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12407733"],"repository":["biostudies-literature"],"pubmed_title":["Mutual Antagonism Between PRC1 Condensates and SWI/SNF in Chromatin Regulation."],"pmcid":["PMC12407733"],"funding_grant_id":["R35 GM131743","K99 GM155610"],"pubmed_authors":["Kingston RE","Marr SK","Schneider PC","Sanon R","Subramanian R","Niekamp S"],"additional_accession":[]},"is_claimable":false,"name":"Mutual Antagonism Between PRC1 Condensates and SWI/SNF in Chromatin Regulation.","description":"Opposing activities of conserved chromatin regulatory complexes, such as the Polycomb Repressive Complex 1 (PRC1) and the activating chromatin remodeler SWI/SNF play critical roles in regulating gene expression during development and differentiation. The mechanisms by which these complexes compete to regulate chromatin states remain poorly understood. We combine single-molecule analysis and genomic approaches in cultured cells to demonstrate that the condensate-forming properties of PRC1 play an important role in excluding SWI/SNF from chromatin. Consistently, PRC1 compositions with a higher propensity for condensate formation are more effective in preventing SWI/SNF binding. Conversely, SWI/SNF-bound chromatin significantly reduces PRC1 binding and subsequent condensate formation. Notably","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-28T03:07:35.096Z","creation":"2026-05-28T03:06:28.172Z"},"accession":"S-EPMC12407733","cross_references":{"pubmed":["40909535"],"doi":["10.1101/2025.08.25.672128"]}}