{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang J"],"funding":["Canada Research Chairs Program of the Natural Sciences and Engineering Research Council","New Frontiers in Research Fund","Natural Sciences and Engineering Research Council Canada Graduate Scholarship Doctoral Program","Canadian Institutes of Health Research"],"pagination":["29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12408339"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(1)"],"pubmed_abstract":["We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating bone defects and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infection using in vitro studies. We successfully synthesized TDNs and demonstrated their excellent cytocompatibility with blood cells and immune cells. Zoledronic acid-loaded TDN displayed increased efficacy compared to free drugs in regulating bone remodeling, while vancomycin-loaded TDN showed an increased antibacterial effect against MRSA. In the future, this nano-drug delivery platform, with its multifunctional properties, can be potentially used to treat bone fractures and surgery-related MRSA infection."],"journal":["NPJ biomedical innovations"],"pubmed_title":["Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applications."],"pmcid":["PMC12408339"],"funding_grant_id":["NFRFE-2019-00743","185629","CRC-2018-00028"],"pubmed_authors":["Huang J","Zahid AA","Luo W","Paul A","Chakraborty A","Shamiya Y"],"additional_accession":[]},"is_claimable":false,"name":"Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applications.","description":"We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating bone defects and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infection using in vitro studies. We successfully synthesized TDNs and demonstrated their excellent cytocompatibility with blood cells and immune cells. Zoledronic acid-loaded TDN displayed increased efficacy compared to free drugs in regulating bone remodeling, while vancomycin-loaded TDN showed an increased antibacterial effect against MRSA. In the future, this nano-drug delivery platform, with its multifunctional properties, can be potentially used to treat bone fractures and surgery-related MRSA infection.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-01T13:48:57.118Z","creation":"2026-04-08T13:11:06.5Z"},"accession":"S-EPMC12408339","cross_references":{"pubmed":["40917680"],"doi":["10.1038/s44385-025-00020-2"]}}